Application of Humanized Mice in Drug Metabolism and Toxicity
文献类型：期刊论文
| 作者 | Wu Zhitao; Ren Jin ; Pan Guoyu
|
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:14页码:1137-1142 |
| 关键词 | humanized mice CYP450 drug metabolism induction inhibition toxicity |
| ISSN号 | 1001-2494 |
| 其他题名 | 人源化小鼠模型在药物代谢和毒性研究中的应用 |
| 文献子类 | Review |
| 英文摘要 | ObjectiveTo discuss the application of humanized mice model in drug metabolism and toxicity. Methods By sorting foreign scientific literature, the history of the development of humanized mice model and its application in drug metabolizing enzymes and toxicity studies were reviewed and summarized to provide support for early drug development. Results AND Conclusion The humanized mice model could reduce interspecies differences and has been increasingly used in drug metabolism and safety evaluation in foreign countries. Transgenic mice can be applied to studying the metabolism of drugs metabolized by certain enzyme. In the chimeric mice body, the disposal of drugs could be more systematic and comprehensive mirrored, predicting this model has enormous potential in drug discovery and development. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4895951 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267767]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Pan Guoyu |
| 作者单位 | Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 200000, China. |
| 推荐引用方式 GB/T 7714 | Wu Zhitao,Ren Jin,Pan Guoyu. Application of Humanized Mice in Drug Metabolism and Toxicity[J]. Chinese Pharmaceutical Journal,2013,48(14):1137-1142. |
| APA | Wu Zhitao,Ren Jin,&Pan Guoyu.(2013).Application of Humanized Mice in Drug Metabolism and Toxicity.Chinese Pharmaceutical Journal,48(14),1137-1142. |
| MLA | Wu Zhitao,et al."Application of Humanized Mice in Drug Metabolism and Toxicity".Chinese Pharmaceutical Journal 48.14(2013):1137-1142. |
入库方式： OAI收割
来源：上海药物研究所
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