The signaling pathway for regulation of glucose transporter 4 and its application in drug development
文献类型：期刊论文
| 作者 | Tang Xuan; Chen Jing ; Shen Xu
|
| 刊名 | Scientia Sinica Chimica
 |
| 出版日期 | 2012 |
| 卷号 | 42期号:12页码:1760-1773 |
| 关键词 | glucose transporter 4 (GLUT4) insulin diabetes GLUT4 translocation |
| ISSN号 | 1674-7224 |
| 其他题名 | 葡萄糖转运蛋白4功能调节信号通路及其在药物研发中的应用 |
| 文献子类 | Review |
| 英文摘要 | Glucose transporter 4 (GLUT4) as a mediator for glucose up-take in skeletal muscle and adipose tissue plays important roles in whole-body glucose metabolism. Impaired glucose disposal is always observed in metabolic disease (such as obesity and type 2 diabetes), and glucose homeostasis can be impacted by alteration of GLUT4 function. Here, we summarize the function, tissue distribution and regulation pathway of GLUT4, and highlight the chemicals in restoring glucose homeostasis via modulating GLUT4 function. Finally, we also discuss the possible research focus of GLUT4 in the future and the association of GLUT4 with other diseases. |
| 资助项目 | 国家自然科学基金项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4718589 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267806]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Chen Jing |
| 作者单位 | Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Tang Xuan,Chen Jing,Shen Xu. The signaling pathway for regulation of glucose transporter 4 and its application in drug development[J]. Scientia Sinica Chimica,2012,42(12):1760-1773. |
| APA | Tang Xuan,Chen Jing,&Shen Xu.(2012).The signaling pathway for regulation of glucose transporter 4 and its application in drug development.Scientia Sinica Chimica,42(12),1760-1773. |
| MLA | Tang Xuan,et al."The signaling pathway for regulation of glucose transporter 4 and its application in drug development".Scientia Sinica Chimica 42.12(2012):1760-1773. |
入库方式： OAI收割
来源：上海药物研究所
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