中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct

文献类型:期刊论文

作者Xing Guozhen; Luan Yang; Ren Jin
刊名Chinese Journal of Pharmacology and Toxicology
出版日期2012
卷号26期号:5页码:706-710
关键词DNA adduct spectrometry mass electrospray ionization
ISSN号1000-3002
其他题名液相-电喷雾离子化-质谱在DNA加合物检测中的应用进展
文献子类Review
英文摘要DNA adducts are an important biomarker predicting DNA damage. Many determination methods have been developed since the discovery of DNA adducts, such as 32P-post labeling, immunological method, liquid chromatography/gas chromatography-mass spectrometer. Recently, with the development of liquid chromatography coupled with mass spectrometer (LC-MS), especially breakthroughs in electrospay ionization (ESI) and progress in mass detection, it is feasible to determine the DNA adducts levels in animal and human tissues after exposure to genetic carcinogens. This paper summarizes the applications of LC-ESI-MS to the determination of base-, nucleoside- and nucleotide-adducts.
资助项目国家科技部重大专项重大新药创制基金[00000000] ; 国家973项目[00000000] ; 国家自然科学基金[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4682125
源URL[http://119.78.100.183/handle/2S10ELR8/267812]  
专题药物安全性评价中心
通讯作者Ren Jin
作者单位Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714
Xing Guozhen,Luan Yang,Ren Jin. Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct[J]. Chinese Journal of Pharmacology and Toxicology,2012,26(5):706-710.
APA Xing Guozhen,Luan Yang,&Ren Jin.(2012).Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct.Chinese Journal of Pharmacology and Toxicology,26(5),706-710.
MLA Xing Guozhen,et al."Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct".Chinese Journal of Pharmacology and Toxicology 26.5(2012):706-710.

入库方式: OAI收割

来源:上海药物研究所

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