Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct
文献类型：期刊论文
| 作者 | Xing Guozhen; Luan Yang; Ren Jin
|
| 刊名 | Chinese Journal of Pharmacology and Toxicology
 |
| 出版日期 | 2012 |
| 卷号 | 26期号:5页码:706-710 |
| 关键词 | DNA adduct spectrometry mass electrospray ionization |
| ISSN号 | 1000-3002 |
| 其他题名 | 液相-电喷雾离子化-质谱在DNA加合物检测中的应用进展 |
| 文献子类 | Review |
| 英文摘要 | DNA adducts are an important biomarker predicting DNA damage. Many determination methods have been developed since the discovery of DNA adducts, such as 32P-post labeling, immunological method, liquid chromatography/gas chromatography-mass spectrometer. Recently, with the development of liquid chromatography coupled with mass spectrometer (LC-MS), especially breakthroughs in electrospay ionization (ESI) and progress in mass detection, it is feasible to determine the DNA adducts levels in animal and human tissues after exposure to genetic carcinogens. This paper summarizes the applications of LC-ESI-MS to the determination of base-, nucleoside- and nucleotide-adducts. |
| 资助项目 | 国家科技部重大专项重大新药创制基金[00000000] ; 国家973项目[00000000] ; 国家自然科学基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4682125 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267812]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Ren Jin |
| 作者单位 | Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Xing Guozhen,Luan Yang,Ren Jin. Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct[J]. Chinese Journal of Pharmacology and Toxicology,2012,26(5):706-710. |
| APA | Xing Guozhen,Luan Yang,&Ren Jin.(2012).Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct.Chinese Journal of Pharmacology and Toxicology,26(5),706-710. |
| MLA | Xing Guozhen,et al."Progress in application of liquid-chromatogram-electrospray ionization-mass spectrum in determination of DNA adduct".Chinese Journal of Pharmacology and Toxicology 26.5(2012):706-710. |
入库方式： OAI收割
来源：上海药物研究所
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