Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists
文献类型：期刊论文
| 作者 | Liu Qing; He Min; Zhou Caihong; Wang Mingwei
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2012 |
| 卷号 | 24期号:7页码:626-633 |
| 关键词 | glucagon-like peptide-1(GLP-1) cyclobutane derivatives diabetes |
| ISSN号 | 1004-0374 |
| 其他题名 | 取代环丁烷结构的非肽类胰高血糖素样肽-1受体激动剂 |
| 文献子类 | Article |
| 英文摘要 | Application of glucagon-like peptide-1(GLP-1) to treat type 2 diabetes has become a focal point in the study of metabolic diseases in recent years.Of particular interest is the unique mechanisms of action relative to GLP-1.It exerts multiple effects on the pathogenesis of type 2 diabetes.While effectively lowering blood glucose levels,it does not cause hypoglycemia but reduces body weight.However,GLP-1 and its peptidic mimetics require frequent injections that limits their wide use.This paper briefly reviews the discovery and pharmacological characterization of a class of novel cyclobutane derivatives as non-peptidic GLP-1 receptor agonists including in vivo efficacies on diabetes and obesity. |
| 资助项目 | 国家重大科技专项十一五和十二五计划[00000000] ; 中国科学院重大项目[00000000] ; 方向性项目[00000000] ; 上海市科委项目[00000000] ; 诺和诺德-中国科学院研究基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4618183 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267823]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Wang Mingwei |
| 作者单位 | The National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Liu Qing,He Min,Zhou Caihong,et al. Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists[J]. Chinese Bulletin of Life Sciences,2012,24(7):626-633. |
| APA | Liu Qing,He Min,Zhou Caihong,&Wang Mingwei.(2012).Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists.Chinese Bulletin of Life Sciences,24(7),626-633. |
| MLA | Liu Qing,et al."Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists".Chinese Bulletin of Life Sciences 24.7(2012):626-633. |
入库方式： OAI收割
来源：上海药物研究所
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