Studies on the cytotoxic constituents from marine actinomycete Micromonospora sp.(M2DG17)
文献类型：期刊论文
| 作者 | HUANG Zhiyun3; TANG Jinshan3; GAO Hao3; LI Yanjun3; HONG Kui1; LI Jia2 ; YAO Xinsheng3
|
| 刊名 | Chinese Journal of Marine Drugs
 |
| 出版日期 | 2011 |
| 卷号 | 30期号:4页码:29-33 |
| 关键词 | actinomycetes secondary metabolites cytotoxicity isolation structural identification |
| ISSN号 | 1002-3461 |
| 其他题名 | 海洋放线菌Micromonospora sp.(M2DG17)细胞毒活性成分研究 |
| 文献子类 | Article |
| 英文摘要 | Objective To study the bioactive secondary metabolites of a marine-derived actinomycete Micromonospora sp.（M2DG17）.Methods By bioassay-guided fractionation,various chromatographic and spectroscopic methods were applied for the isolation and structural identification of pure compounds from the broth of Micromonospora sp.（M2DG17）,and the bioactivities of pure compounds were also evaluated.Results Seven compounds were obtained from the broth of Micromonospora sp.（M2DG17） and their structures were identified as 3-hydroxymethyl-beta-carboline（1）,3-methyl-beta-carboline（2）,beta-carboline（3）,Cyclo-L-Pro-L-Phe)（4）,Cyclo-（L-Pro-L-Val）（5）,Cyclo-（L-Pro-L-Leu）（6）,and Cyclo-（L-Pro-L-Ile）（7）,respectively.Conclusion Compounds 14 and 6 were isolated from the genus of Micromonospora sp.for the first time,and compound 2 showed weak inhibitory effect on HCT 116 cell lines with IC50 value of 65.0 mumol·L-1. |
| 资助项目 | 国家自然科学基金委与广东省人民政府联合基金[00000000] ; 特境微生物新活性物质的发现[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4273034 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267867]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 作者单位 | 1.Institute of Tropical Biosciences and Biotechnology,Chinese Academy of Tropical Agriculture Sciences, Haikou, Hainan 570110, China.; 2.National Center for Drug Screening,Shanghai Institute of Medica Materia,Chinese Academy of Sciences, Shanghai 201203, China. 3.Institute of Traditional Chinese Medicine and Natural Products,Jinan University, Guangzhou, Guangdong 510632, China.; |
| 推荐引用方式 GB/T 7714 | HUANG Zhiyun,TANG Jinshan,GAO Hao,et al. Studies on the cytotoxic constituents from marine actinomycete Micromonospora sp.(M2DG17)[J]. Chinese Journal of Marine Drugs,2011,30(4):29-33. |
| APA | HUANG Zhiyun.,TANG Jinshan.,GAO Hao.,LI Yanjun.,HONG Kui.,...&YAO Xinsheng.(2011).Studies on the cytotoxic constituents from marine actinomycete Micromonospora sp.(M2DG17).Chinese Journal of Marine Drugs,30(4),29-33. |
| MLA | HUANG Zhiyun,et al."Studies on the cytotoxic constituents from marine actinomycete Micromonospora sp.(M2DG17)".Chinese Journal of Marine Drugs 30.4(2011):29-33. |
入库方式： OAI收割
来源：上海药物研究所
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