Role of angiotensin converting enzyme 2 in pathogenesis of severe acute respiratory syndrome
文献类型：期刊论文
| 作者 | ZHANG YunHai; GONG LiKun ; REN Jin
|
| 刊名 | Chinese Journal of Pharmacology and Toxicology
 |
| 出版日期 | 2007 |
| 卷号 | 21期号:1页码:72-76 |
| 关键词 | angiotensin converting enzyme 2 severe acute respiratory syndrome acute lung injury |
| ISSN号 | 1000-3002 |
| 其他题名 | 血管紧张素转换酶2在SARS病理途径中的作用 |
| 文献子类 | Review |
| 英文摘要 | Infection of human severe acute respiratory syndrome-associated coronavirus （SARS-CoV） can lead to serious lung injury symptoms which resemble the acute lung injury （ALI） and acute respiratory distress syndrome （ARDS）. Human angiotensin converting enzyme（ ACE ） 2 has been recognized as the specific binding receptor of SARS-CoV spike protein （S protein）, and the efficiency of their binding is relative to the replication and infection ability of SARS-CoV. The balance between ACE1 and ACE2 is crucial for the normal function of lung, in which the stability of functional ACE2 can attenuate the severity of ALI and ARDS. In infection of SARS-CoV, S protein of SARS- CoV binds to the human ACE2 and down-regulates the ACE2 level. Then it follows the unbalance between ACE2 and ACE1, which leads AT_1 receptor to be over stimulated by increasing angiotensin 11 level. The pulmonary edema and symptom of ALI in SARS patients can be due to the leaky pulmonary blood vessels through over-stimulation of AT, receptor. Therefore, ACE2 is a key molecule involved in the development and progression of SARS. |
| WOS研究方向 | General & Internal Medicine ; Biochemistry & Molecular Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2744249 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268127]  |
| 专题 | 药物安全性评价中心 |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHANG YunHai,GONG LiKun,REN Jin. Role of angiotensin converting enzyme 2 in pathogenesis of severe acute respiratory syndrome[J]. Chinese Journal of Pharmacology and Toxicology,2007,21(1):72-76. |
| APA | ZHANG YunHai,GONG LiKun,&REN Jin.(2007).Role of angiotensin converting enzyme 2 in pathogenesis of severe acute respiratory syndrome.Chinese Journal of Pharmacology and Toxicology,21(1),72-76. |
| MLA | ZHANG YunHai,et al."Role of angiotensin converting enzyme 2 in pathogenesis of severe acute respiratory syndrome".Chinese Journal of Pharmacology and Toxicology 21.1(2007):72-76. |
入库方式： OAI收割
来源：上海药物研究所
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