Design and synthesis of aralkyl-ketone piperazine derivatives and their antalgic activities
文献类型：期刊论文
| 作者 | LI Jianqi1; HUANG Liying1; CHEN Jianxin2; WENG Zhijie1; ZHANG Chunnian1 |
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 42期号:11页码:1166-1175 |
| 关键词 | aralkyl-ketone piperazine derivatives synthesis analgesic activity |
| ISSN号 | 0513-4870 |
| 其他题名 | 芳烷酮哌嗪衍生物的设计合成及镇痛活性 |
| 文献子类 | Article |
| 英文摘要 | To synthesize aralkyl-ketone piperazine derivatives as analgesic agents,the N atom of the one side of piperazine ring is protected by formyl group firstly,then the unprotected N atom is alkylated to prepare aralkyl-ketone piperazine derivatives.Their analgesic biological activities were well studied by mice writhing model,rat hot plate model and rat tail flick model.Sixty four compounds were synthesized and pharmacological tests in vivo revealed these compounds have potent analgesic activities,especially compound I_(12),I_(14),I_(21) and I_(37).These four compounds are more worthy for further research. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3012234 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268167]  |
| 专题 | 药物安全性评价中心 |
| 作者单位 | 1.Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.; 2.Shanghai Institute of Materia Medica, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LI Jianqi,HUANG Liying,CHEN Jianxin,et al. Design and synthesis of aralkyl-ketone piperazine derivatives and their antalgic activities[J]. Acta Pharmaceutica Sinica,2007,42(11):1166-1175. |
| APA | LI Jianqi,HUANG Liying,CHEN Jianxin,WENG Zhijie,&ZHANG Chunnian.(2007).Design and synthesis of aralkyl-ketone piperazine derivatives and their antalgic activities.Acta Pharmaceutica Sinica,42(11),1166-1175. |
| MLA | LI Jianqi,et al."Design and synthesis of aralkyl-ketone piperazine derivatives and their antalgic activities".Acta Pharmaceutica Sinica 42.11(2007):1166-1175. |
入库方式： OAI收割
来源：上海药物研究所
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