Neuroprotective effects of stearic acid in primarily cultured hippocampal neurons insulted by excitotoxicity
文献类型：期刊论文
| 作者 | Li Guanghai2; Wang Zejian2; Chen Xueqin1; Hu Guoyuan1; Yin Ming2 |
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2006 |
| 卷号 | 22期号:11页码:1348-1352 |
| 关键词 | stearic acid excitotoxicity PPAR-gamma |
| ISSN号 | 1001-1978 |
| 其他题名 | 硬脂酸对兴奋性损伤的原代培养海马细胞的神经保护作用 |
| 文献子类 | Article |
| 英文摘要 | Aim To evaluate neuroprotective effects of stearic acid on primarily cultured hippocampal neurons and to study the mechanism of neuroprotection afforded by stearic acid. Methods Primarily cultured hippocampal neurons were insulted by OGD (oxygen-glucose deprivation), H_2O_2, glutamate and NaN_3; MTT assay was utilized to evaluate cell viability; Inhibitors of PPAR-gammaand PI-3 K signal pathway were used to study mechanisms of neuroprotection of stearic acid. Results Compared with control neurons, A_(570) in MTT assay were increased significantly by stearic acid in hippocampal neurons insulted by OGD (oxygen-glucose deprivation), H_2O_2 and glutamate (P<0.05); Stearic acid had no effects on A570 in MTT assay in neurons insulted by NaN_3; Neuroproleclive effects afforded by stearic acid could be cancelled by BADGE ( inhibitor of PPAR-y) and wortmannin (inhibitor of PI-3K signal pathway). Conclusions Stearic acid can dosage-de-pendently protect hippocampal neurons; Integrality of mitochondrial was vital in neuroprotective effects afforded by stearic acid; PPARgammaand PI-3K signal pathway mediated the neuroprotection. |
| 资助项目 | 上海市科委资助项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2618324 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268215]  |
| 专题 | 神经药理学研究国际科学家工作站 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China.; |
| 推荐引用方式 GB/T 7714 | Li Guanghai,Wang Zejian,Chen Xueqin,et al. Neuroprotective effects of stearic acid in primarily cultured hippocampal neurons insulted by excitotoxicity[J]. Chinese Pharmacological Bulletin,2006,22(11):1348-1352. |
| APA | Li Guanghai,Wang Zejian,Chen Xueqin,Hu Guoyuan,&Yin Ming.(2006).Neuroprotective effects of stearic acid in primarily cultured hippocampal neurons insulted by excitotoxicity.Chinese Pharmacological Bulletin,22(11),1348-1352. |
| MLA | Li Guanghai,et al."Neuroprotective effects of stearic acid in primarily cultured hippocampal neurons insulted by excitotoxicity".Chinese Pharmacological Bulletin 22.11(2006):1348-1352. |
入库方式： OAI收割
来源：上海药物研究所
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