Enhanced antiangiogenic and antitumoral efficacy by combining endostatin with batimastat
文献类型：期刊论文
| 作者 | Xin J(欣坚); Ma XC(马小超); Deng H(邓辉); Zhang T(张婷); Tu CH(屠曾宏) |
| 刊名 | Chinese Journal of Pharmacology and Toxicology
 |
| 出版日期 | 2003 |
| 卷号 | 17期号:5页码:384-388 |
| 关键词 | endostatin batimastat angiogenesis carcinoma, Lewis lung |
| ISSN号 | 1000-3002 |
| 其他题名 | 内皮抑制素与巴马司他合用提高抗血管新生和抗肿瘤功效 |
| 文献子类 | Article |
| 英文摘要 | AIM To show a combination of endostatin with batimastat has more potent antiangiogenic and antitumor effect. METHODS Capillary-like tube formation assay was used to determine angiogenesis in vitro. Hemoglobin content was detected to assess angiogenesis in vivo. Mice were implanted with Lewis lung carcinoma cells, and tumor weight was measured after 12 d treatment. RESULTS Endostatin treatment alone reduced capillary-like tube numbers in vitro (inhibitory rate 33.5%) and hemoglobin content in vivo (inhibitory rate 38.8%); while in the both assays, the combined treatment of endostatin with batimastat all resulted in a significantly enhanced inhibitory efficacy compared with endostatin treatment alone (P<0.05). Tumor weight was reduced by 46.3% in mice treated with endostatin alone; and by 65.7% in mice treated with the combined therapy. CONCLUSION The addition of batimastat to endostatin enhanced antiangiogenic and antitumoral efficacy. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1494369 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268440]  |
| 专题 | 药物安全性评价中心 |
| 作者单位 | 1.Department of Dermatology, Huashan Hospital, Medical Department of Fudan University, ShangHai 200040, China. 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, ShangHai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Xin J,Ma XC,Deng H,et al. Enhanced antiangiogenic and antitumoral efficacy by combining endostatin with batimastat[J]. Chinese Journal of Pharmacology and Toxicology,2003,17(5):384-388. |
| APA | 欣坚,马小超,邓辉,张婷,&屠曾宏.(2003).Enhanced antiangiogenic and antitumoral efficacy by combining endostatin with batimastat.Chinese Journal of Pharmacology and Toxicology,17(5),384-388. |
| MLA | 欣坚,et al."Enhanced antiangiogenic and antitumoral efficacy by combining endostatin with batimastat".Chinese Journal of Pharmacology and Toxicology 17.5(2003):384-388. |
入库方式： OAI收割
来源：上海药物研究所
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