Endostatin inhibits angiogenesis by suppressing matrix metalloproteinase-2
文献类型：期刊论文
| 作者 | Xin J(欣坚); Ma XC(马小超); Deng H(邓辉); Zhang T(张婷); Tu CH(屠曾宏) |
| 刊名 | Chinese Journal of Pharmacology and Toxicology
 |
| 出版日期 | 2003 |
| 卷号 | 17期号:5页码:389-394 |
| 关键词 | endostatin fibroblast growth factor, basic umbilical veins matrix metalloproteinase |
| ISSN号 | 1000-3002 |
| 其他题名 | 内皮抑制素通过抑制基质金属蛋白酶-2而抑制血管新生 |
| 文献子类 | Article |
| 英文摘要 | AIM To study mechanisms involved in antiangiogenic effect of endostatin. METHODS Human umbilical vein endothelial cells (HUVEC) were isolated and treated with basic fibroblast growth factor (bFGF). 3D-collagen gel model was used to determine the angiogenesis of HUVEC. Activity of matrix metalloproteinase (MMP) in culture medium was analyzed by gelatin zymography and Western blot. RT-PCR was used to determine mRNA levels of MMP. RESULTS Endostatin inhibited the angiogenesis of HUVEC induced by bFGF. Endostatin inhibited the expression and the mRNA level of MMP-2 in a concentration-dependent manner. CONCLUSION MMP-2 inhibition plays an important role in antiangiogenic effect of endostatin. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1494387 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268441]  |
| 专题 | 药物安全性评价中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, ShangHai 201203, China.; 2.Department of Dermatology, Huashan Hospital, Medical Department of Fudan University, ShangHai 200040, China. |
| 推荐引用方式 GB/T 7714 | Xin J,Ma XC,Deng H,et al. Endostatin inhibits angiogenesis by suppressing matrix metalloproteinase-2[J]. Chinese Journal of Pharmacology and Toxicology,2003,17(5):389-394. |
| APA | 欣坚,马小超,邓辉,张婷,&屠曾宏.(2003).Endostatin inhibits angiogenesis by suppressing matrix metalloproteinase-2.Chinese Journal of Pharmacology and Toxicology,17(5),389-394. |
| MLA | 欣坚,et al."Endostatin inhibits angiogenesis by suppressing matrix metalloproteinase-2".Chinese Journal of Pharmacology and Toxicology 17.5(2003):389-394. |
入库方式： OAI收割
来源：上海药物研究所
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