Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro
文献类型：期刊论文
| 作者 | Yu Xiaolu1; Sun Jianhua1 ; Gong Likun1
|
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2018 |
| 卷号 | 34期号:9页码:1185-1189 |
| 关键词 | TGN1412 monoclonal antibody cytokine-release syndrome TGN1412 cytokine release assay in vitro minimum anticipated biological effect level preclinical safety study |
| ISSN号 | 1001-1978 |
| 其他题名 | 单抗诱发性细胞因子释放综合征和体外细胞因子释放实验的研究进展 |
| 文献子类 | Review |
| 英文摘要 | Cytokine-release syndrome (CRS) triggered by monoclonal antibodies (mAbs) is characterized by rapid onset and severe damage,and difficulty in prediction and control. Recent years, it has been a research focus on establishing a reliable animal model in vivo and cytokine release assay(CRA) in vitro to predict CRS for preclinical safety evaluation. In this paper we summarize matters related to CRA applicable objects,considerations of method design and method optimization,aiming to provide suggestions for the optimization of CRA prediction platform. |
| 资助项目 | 国家科技部重大新药创制科技重大专项[00000000] ; 中科院药物所创新研究院自主部署项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6323339 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269159]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Gong Likun |
| 作者单位 | 1.School of Pharmacy,University of Chinese Academy of Sciences; 2.Beijing 3.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,; 4.; |
| 推荐引用方式 GB/T 7714 | Yu Xiaolu,Sun Jianhua,Gong Likun. Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro[J]. Chinese Pharmacological Bulletin,2018,34(9):1185-1189. |
| APA | Yu Xiaolu,Sun Jianhua,&Gong Likun.(2018).Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro.Chinese Pharmacological Bulletin,34(9),1185-1189. |
| MLA | Yu Xiaolu,et al."Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro".Chinese Pharmacological Bulletin 34.9(2018):1185-1189. |
入库方式： OAI收割
来源：上海药物研究所
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