The Fate of Cells:Pharmacokinetics of MSC
文献类型：期刊论文
| 作者 | Han Li2; Hui Lijian5; Pan Guoyu2
|
| 刊名 | Chinese Journal of Cell Biology
 |
| 出版日期 | 2018 |
| 卷号 | 40期号:6页码:857-866 |
| 关键词 | PK/PD/TD MSC pharmacokinetics PK/PD/TD |
| ISSN号 | 1674-7666 |
| 其他题名 | 细胞的命运:间充质干细胞的药代动力学 |
| 文献子类 | Article |
| 英文摘要 | Recently,cellular drugs have become one of the hottest areas in drug development.Cellular drugs are quite different from the traditional small molecules and macromolecular drugs,because of their proliferation and chemotactic abilities.With the help of pharmacokinetic theories,it would be feasible to describe and predict the fate of cell drug,characterize their distribution,metabolism,and elimination in the body.That will improve the clinical efficacy and safety of the cellular drugs,reduce the risk of drug-drug interactions.In this paper,we take mesenchymal stem cell (MSC) as an example,trying to clarify the relationship between the pharmacokinetics and the efficacy/toxicity (PK/PD/TD) of cell drugs according to published literatures. |
| 资助项目 | 中国科学院器官重建与制造战略性先导科技专项资助[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6277567 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269167]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Pan Guoyu |
| 作者单位 | 1.Shanghai Institute of Life Sciences,Chinese Academy of Science,; 2.Shanghai Institute of Materia Medica,Chinese Academy of Science; 3.; 4.Shanghai; 5.University of Chinese Academy of Sciences; 6.Beijing |
| 推荐引用方式 GB/T 7714 | Han Li,Hui Lijian,Pan Guoyu. The Fate of Cells:Pharmacokinetics of MSC[J]. Chinese Journal of Cell Biology,2018,40(6):857-866. |
| APA | Han Li,Hui Lijian,&Pan Guoyu.(2018).The Fate of Cells:Pharmacokinetics of MSC.Chinese Journal of Cell Biology,40(6),857-866. |
| MLA | Han Li,et al."The Fate of Cells:Pharmacokinetics of MSC".Chinese Journal of Cell Biology 40.6(2018):857-866. |
入库方式： OAI收割
来源：上海药物研究所
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