The Roles of 53BP1 in DNA Double-strand Breaks Repair
文献类型：期刊论文
| 作者 | Jiang Yuejing; Zang Yi
|
| 刊名 | Chinese Journal of Biochemistry and Molecular Biology
 |
| 出版日期 | 2016 |
| 卷号 | 32期号:12页码:1279-1285 |
| 关键词 | tumor suppressor p53 binding protein 1 DNA double-strand breaks DNA damage repair |
| ISSN号 | 1007-7626 |
| 其他题名 | 53BP1与DNA双链断裂损伤修复 |
| 文献子类 | Review |
| 英文摘要 | The accurate replication and transmission of genetic material are important to maintain genomic stability. DNA double-strand breaks might result in cellular apoptosis and chromosomal rearrangements,which induce the development of tumor. 53BP1 is an important mediator in DNA doublestrand breaks repair,which functions in keeping the balance of repair pathway choice and preserving genomic stability. In this paper we focus on 53BP1's protein structure,biological functions,signaling pathways,molecular mechanisms and post-translational modifications,hoping to provide some theoretical basis for the further study. |
| 资助项目 | 国家自然科学基金项目[00000000] |
| WOS研究方向 | Cell Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5879507 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269223]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Zang Yi |
| 作者单位 | Shanghai Institute of Material Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Jiang Yuejing,Zang Yi. The Roles of 53BP1 in DNA Double-strand Breaks Repair[J]. Chinese Journal of Biochemistry and Molecular Biology,2016,32(12):1279-1285. |
| APA | Jiang Yuejing,&Zang Yi.(2016).The Roles of 53BP1 in DNA Double-strand Breaks Repair.Chinese Journal of Biochemistry and Molecular Biology,32(12),1279-1285. |
| MLA | Jiang Yuejing,et al."The Roles of 53BP1 in DNA Double-strand Breaks Repair".Chinese Journal of Biochemistry and Molecular Biology 32.12(2016):1279-1285. |
入库方式： OAI收割
来源：上海药物研究所
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