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Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling

文献类型：期刊论文

作者Zhang Cuifeng1; Xie Haitang2; Pan Guoyu3
刊名Acta Pharmaceutica Sinica
出版日期2016
卷号51期号:8页码:1202-1208
关键词macromolecule pharmacokinetics model monoclonal antibodies
ISSN号0513-4870
其他题名大分子药物的吸收、分布、代谢、排泄和毒性特征及药代模型的应用
文献子类Review
英文摘要Recently, more and more attentions of drug development are placed to macromolecules, such as monoclonal antibodies, proteins, etc. It has become one of the most promising areas in drug research and development in 21st Century. In terms of the structure and the ADMET (absorption, distribution, metabolism, excretion and toxicity), macromolecules is different from small molecule drugs, which lead to a distinct modeling strategy. The characterization of biologics ADMET processes and its application in the PK model selection of macromolecules are reviewed in this paper.
资助项目国家自然科学基金资助项目[00000000] ; 安徽高校自然科学研究项目[00000000] ; 2016年高校优秀青年人才支持计划重点项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5768137
源URL[http://119.78.100.183/handle/2S10ELR8/269245]  
专题药物安全性评价中心
通讯作者Pan Guoyu
作者单位1.Wannan Medical College, Wuhu, Anhui 241000, China.;
2.Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, China.;
3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200120, China.
推荐引用方式
GB/T 7714		 Zhang Cuifeng,Xie Haitang,Pan Guoyu. Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling[J]. Acta Pharmaceutica Sinica,2016,51(8):1202-1208.
APA Zhang Cuifeng,Xie Haitang,&Pan Guoyu.(2016).Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling.Acta Pharmaceutica Sinica,51(8),1202-1208.
MLA Zhang Cuifeng,et al."Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling".Acta Pharmaceutica Sinica 51.8(2016):1202-1208.

入库方式： OAI收割

来源：上海药物研究所

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