A novel target for cancer therapyeEF2K
文献类型：期刊论文
| 作者 | Xiao Ting; Liu Rui; Wang Mingwei
|
| 刊名 | Chemistry of Life
 |
| 出版日期 | 2016 |
| 卷号 | 36期号:3页码:397-403 |
| 关键词 | eukaryotic elongation factor 2 kinase (eEF2K) elongation eEF2K inhibitors high-throughput drug screening |
| ISSN号 | 1000-1336 |
| 其他题名 | 癌症治疗的新靶点eEF2K |
| 文献子类 | Review |
| 英文摘要 | Eukaryotic elongation factor 2 kinase (eEF2K) is encoded by the human eEF2K gene. It belongs to an atypical protein kinase family named as alpha-kinase. The activity of eEF2K depends on Ca~(2+) and calmodulin. Under the condition of certain metabolic stress eEF2K can phosphorylate the eukaryotic elongation factor 2 (eEF2) to restrain its activity, to inhibit elongation of polypeptide chains in the process of protein synthesis, and to reduce energy and amino acid consumption, thereby helping cells survive through nutrition deprivation conditions. eEF2K is thus implicated to be a novel drug target for cancer treatment. In conjunction with some newly reported small molecule eEF2K inhibitors, the potential therapeutic value of eEF2K is discussed in this review. |
| 资助项目 | 国家科技重大专项[00000000] ; 上海市科学技术委员会基金项目[00000000] |
| WOS研究方向 | Oncology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5744622 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269246]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Wang Mingwei |
| 作者单位 | The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Xiao Ting,Liu Rui,Wang Mingwei. A novel target for cancer therapyeEF2K[J]. Chemistry of Life,2016,36(3):397-403. |
| APA | Xiao Ting,Liu Rui,&Wang Mingwei.(2016).A novel target for cancer therapyeEF2K.Chemistry of Life,36(3),397-403. |
| MLA | Xiao Ting,et al."A novel target for cancer therapyeEF2K".Chemistry of Life 36.3(2016):397-403. |
入库方式： OAI收割
来源：上海药物研究所
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