KCNQ1 potassium channel and its small molecular modulator
文献类型：期刊论文
| 作者 | Lan Xi; Li Min; Gao Zhaobing
|
| 刊名 | Chinese Journal of New Drugs and Clinical Remedies
 |
| 出版日期 | 2013 |
| 卷号 | 32期号:11页码:843-849 |
| 关键词 | KCNE KCNQ1 potassium channel KCNE arrhythmia action potentials small molecular activator high throughput screening |
| ISSN号 | 1007-7669 |
| 其他题名 | KCNQ1钾离子通道及其小分子调节剂 |
| 文献子类 | Review |
| 英文摘要 | Voltage-gated KCNQ1 potassium channel is predominately expressed in cardiac tissue. Being the alpha subunit, KCNQ1 co-assembles with its auxiliary subunit, KCNE1, to form a channel complex. The complex constitutes one slow delayed rectifier current known as IKs. IKs is partly responsible for terminating of the cardiac potential. Mutations of KCNQl genes that result in reduction or loss of channel activity cause long QT syndrome, a life - threatening cardiac disease, which includes serious arrhythmia, ventricular fibrillation and sudden death. Activators have been an attractive strategy to rescue the dysfunction of KCNQl channels. This paper reviews the current knowledge about physiological function and small chemical modulators of KCNQ1 channel. |
| 资助项目 | 中国国家自然基金面上项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5008883 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269359]  |
| 专题 | 神经药理学研究国际科学家工作站 |
| 作者单位 | International Scientist Workstation of Neuropharmacology, Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Lan Xi,Li Min,Gao Zhaobing. KCNQ1 potassium channel and its small molecular modulator[J]. Chinese Journal of New Drugs and Clinical Remedies,2013,32(11):843-849. |
| APA | Lan Xi,Li Min,&Gao Zhaobing.(2013).KCNQ1 potassium channel and its small molecular modulator.Chinese Journal of New Drugs and Clinical Remedies,32(11),843-849. |
| MLA | Lan Xi,et al."KCNQ1 potassium channel and its small molecular modulator".Chinese Journal of New Drugs and Clinical Remedies 32.11(2013):843-849. |
入库方式： OAI收割
来源：上海药物研究所
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