The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine
文献类型：期刊论文
| 作者 | Xiao, Ling1,2; Xue, Yaru1,2; Zhang, Cuifeng1,2; Wang, Le1,2; Lin, Yunfei1,2; Pan, Guoyu1,2
|
| 刊名 | XENOBIOTICA
 |
| 出版日期 | 2018 |
| 卷号 | 48期号:3页码:314-323 |
| 关键词 | Berberine MATE1 hepatobiliary distribution excretion DDIs |
| ISSN号 | 0049-8254 |
| DOI | 10.1080/00498254.2017.1300707 |
| 文献子类 | Article |
| 英文摘要 | 1. Berberine (BBR), an isoquinoline alkaloid, has demonstrated multiple clinical pharmacological actions. As a substrate of multiple transporters in the liver, BBR is rarely excreted into the bile but can be found in the urine. The purpose of the present study was to investigate the role of multidrug and toxin extrusion protein 1 (MATE1) in the transport of BBR in the liver and kidney. 2. Using human MATE1 (hMATE1)-transfected HEK293 cells, BBR was shown to be a substrate of hMATE1 (K-m = 4.28 +/- 2.18 mu M). In primary rat hepatocytes, pH-dependent uptake and efflux studies suggested that the transport of BBR was driven by the exchange of H+ and involved Mate1. In rats, we found that pyrimethamine (PYR), an inhibitor of Mate1, increased hepatic and renal distribution of BBR and decreased systematic excretion of BBR. 3. These findings indicated that BBR is a substrate of MATE1 and that hepatic and renal Mate1 promote excretion of BBR into bile and urine, respectively. In conclusion, Mate1 plays a key role in the distribution and excretion of BBR, and we speculate that drug-drug interactions (DDIs) caused by MATE1 may occur between BBR and other co-administered drugs. |
| WOS关键词 | SANDWICH-CULTURED HEPATOCYTES ; P-GLYCOPROTEIN ; TRANSPORTER PROTEIN ; CATION ANTIPORTERS ; BILIARY-EXCRETION ; DRUG-INTERACTIONS ; RENAL CLEARANCE ; RAT HEPATOCYTES ; ORGANIC CATIONS ; MATE1 |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000426958800010 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272328]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Pan, Guoyu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Ling,Xue, Yaru,Zhang, Cuifeng,et al. The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine[J]. XENOBIOTICA,2018,48(3):314-323. |
| APA | Xiao, Ling,Xue, Yaru,Zhang, Cuifeng,Wang, Le,Lin, Yunfei,&Pan, Guoyu.(2018).The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine.XENOBIOTICA,48(3),314-323. |
| MLA | Xiao, Ling,et al."The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine".XENOBIOTICA 48.3(2018):314-323. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。