Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187
文献类型：期刊论文
| 作者 | Choochuay, Jutatip2,3; Xu, Xin1,4; Rukachaisirikul, Vatcharin2,3; Guedduaythong, Piyada2,3; Phongpaichit, Souwalak5,6; Sakayaroj, Jariya7; Chen, Jing4 ; Shen, Xu4
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2017-12 |
| 卷号 | 22页码:122-127 |
| 关键词 | Aspergillus polyporicola Cytochalasins Curvularins Soil-derived fungi Antimicrobial activity Cytotoxic activity |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2017.09.011 |
| 文献子类 | Article |
| 英文摘要 | Two new curvularin derivatives, curvulopyran (1) and ent-curvulone A (2), along with ten known compounds including five cytochalasins and five curvularins, were isolated from a culture broth of the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. Their structures were determined by spectroscopic methods. Known aspochalasin D displayed moderate antifungal activity against flucytosine-resistant Cryptococcus neoformans with an MIC value of 32 mu g/mL and showed no cytotoxic activity against noncancerous cell lines. In addition, known alpha, beta-dehydrocurvularin exhibited potential cytotoxic activity against both KB and MCF-7 cell lines with the IC50 values of 11.26 and 19.50 mu M. Unfortunately, it was strongly active against Vero cell lines. |
| WOS关键词 | CYTOTOXICITY ; RHIZOSPHERE ; METABOLITES ; CELLS |
| 资助项目 | Thailand Research Fund[DBG5980001] ; NSFC-TRF co-project[81561148011] ; Faculty of Science, Prince of Songkla University[00000000] ; Center of Excellence for Innovation in Chemistry (PERCH-CIC)[00000000] ; Graduate School, Prince of Songkla University[00000000] ; National Science and Technology Development Agency[00000000] ; NSTDA Chair Professor grant (the Fourth Grant) of the Crown Property Bureau Foundation[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000415919100023 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272384]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Rukachaisirikul, Vatcharin |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand; 3.Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Songkhla, Thailand; 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 5.Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90112, Songkhla, Thailand; 6.Prince Songkla Univ, Fac Sci, Nat Prod Res Ctr Excellence, Hat Yai 90112, Songkhla, Thailand; 7.Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk, Klongluang 12120, Pathumthani, Thailand |
| 推荐引用方式 GB/T 7714 | Choochuay, Jutatip,Xu, Xin,Rukachaisirikul, Vatcharin,et al. Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187[J]. PHYTOCHEMISTRY LETTERS,2017,22:122-127. |
| APA | Choochuay, Jutatip.,Xu, Xin.,Rukachaisirikul, Vatcharin.,Guedduaythong, Piyada.,Phongpaichit, Souwalak.,...&Shen, Xu.(2017).Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187.PHYTOCHEMISTRY LETTERS,22,122-127. |
| MLA | Choochuay, Jutatip,et al."Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187".PHYTOCHEMISTRY LETTERS 22(2017):122-127. |
入库方式： OAI收割
来源：上海药物研究所
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