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Cytosporone derivatives from the endophytic fungus Phomopsis sp PSU-H188

文献类型：期刊论文

作者Kongprapan, Thippaya5,6; Xu, Xin1,7; Rukachaisirikul, Vatcharin5,6; Phongpaichit, Souwalak2,3; Sakayaroj, Jariya4; Chen, Jing7; Shen, Xu7
刊名PHYTOCHEMISTRY LETTERS
出版日期2017-12
卷号22页码:219-223
关键词Phomopsis sp. Hevea brasiliensis Cytosporone Antibacterial activity Cytotoxic activity Glucose output inhibitory activity Protection of pancreatic beta-cells
ISSN号1874-3900
DOI10.1016/j.phytol.2017.10.002
文献子类Article
英文摘要Two new cytosporone derivatives (1 and 2) were isolated from the endophytic fungus Phomopsis sp. PSU-H188 together with 19 known compounds. Their structures were elucidated by analysis of spectroscopic data. Known mycoepoxydiene showed potent cytotoxic activity towards both MCF-7 and noncancerous Vero cell lines with the respective IC50 values of 9.27 and 4.06 mu M. It exhibited inhibition on glucose output in mouse primary hepatocytes with the IC50 value of 16.06 mu M, but did not show cytotoxicity on primary mouse hepatocytes. Additionally, known cytosporone B displayed protective activity against INS-1 832/13 pancreatic beta-cells by an EC50 value of 11.08 mu M whereas known diaporthalasin displayed antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 4 mu g/mL. Both of them were noncytotoxic to Vero cells.
WOS关键词SECONDARY METABOLITES ; MANGROVE ; CELLS ; MICE
资助项目Thailand Research Fund[DBG5980001] ; NSFC-TRF co-project[81561148011] ; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Prince of Songkla University[00000000] ; Graduate School, Faculty of Science, Prince of Songkla University[00000000] ; Department of Chemistry, Faculty of Science, Prince of Songkla University[00000000] ; Crown Property Bureau Foundation[00000000] ; National Science and Technology Development Agency[00000000] ; Faculty of Science, Prince of Songkla University[00000000]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000415919100043
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/272385]  
专题药物安全性评价中心
通讯作者Rukachaisirikul, Vatcharin
作者单位1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
2.Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90112, Songkhla, Thailand;
3.Prince Songkla Univ, Fac Sci, Nat Prod Res Ctr Excellence, Hat Yai 90112, Songkhla, Thailand;
4.Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk, Klongluang 12120, Pathumthani, Thailand
5.Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand;
6.Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Songkhla, Thailand;
7.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Kongprapan, Thippaya,Xu, Xin,Rukachaisirikul, Vatcharin,et al. Cytosporone derivatives from the endophytic fungus Phomopsis sp PSU-H188[J]. PHYTOCHEMISTRY LETTERS,2017,22:219-223.
APA Kongprapan, Thippaya.,Xu, Xin.,Rukachaisirikul, Vatcharin.,Phongpaichit, Souwalak.,Sakayaroj, Jariya.,...&Shen, Xu.(2017).Cytosporone derivatives from the endophytic fungus Phomopsis sp PSU-H188.PHYTOCHEMISTRY LETTERS,22,219-223.
MLA Kongprapan, Thippaya,et al."Cytosporone derivatives from the endophytic fungus Phomopsis sp PSU-H188".PHYTOCHEMISTRY LETTERS 22(2017):219-223.

入库方式： OAI收割

来源：上海药物研究所

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