The 3D characteristics of post-traumatic syringomyelia in a rat model: a propagation-based synchrotron radiation microtomography study
文献类型：期刊论文
| 作者 | Liao, Shenghui2; Ni, Shuangfei1,5; Cao, Yong1,5; Yin, Xianzhen4; Wu, Tianding1,5; Lu, Hongbin1,3; Hu, Jianzhong1,5; Wu, Hao5; Lang, Ye5 |
| 刊名 | JOURNAL OF SYNCHROTRON RADIATION
 |
| 出版日期 | 2017-11 |
| 卷号 | 24页码:1218-1225 |
| 关键词 | post-traumatic syringomyelia three-dimensional propagation-based synchrotron radiation microtomography spinal cord injury phase-contrast tomography |
| ISSN号 | 1600-5775 |
| DOI | 10.1107/S1600577517011201 |
| 文献子类 | Article |
| 英文摘要 | Many published literature sources have described the histopathological characteristics of post-traumatic syringomyelia (PTS). However, three-dimensional (3D) visualization studies of PTS have been limited due to the lack of reliable 3D imaging techniques. In this study, the imaging efficiency of propagation-based synchrotron radiation microtomography (PB-SR mu CT) was determined to detect the 3D morphology of the cavity and surrounding microvasculature network in a rat model of PTS. The rat model of PTS was established using the infinite horizon impactor to produce spinal cord injury (SCI), followed by a subarachnoid injection of kaolin to produce arachnoiditis. PB-SR mu CT imaging and histological examination, as well as fluorescence staining, were conducted on the animals at the tenth week after SCI. The 3D morphology of the cystic cavity was vividly visualized using PB-SR mu CT imaging. The quantitative parameters analyzed by PB-SR mu CT, including the lesion and spared spinal cord tissue area, the minimum and maximum diameters in the cystic cavity, and cavity volume, were largely consistent with the results of the histological assessment. Moreover, the 3D morphology of the cavity and surrounding angioarchitecture could be simultaneously detected on the PB-SR mu CT images. This study demonstrated that high-resolution PB-SR mu CT could be used for the 3D visualization of trauma-induced spinal cord cavities and provides valuable quantitative data for cavity characterization. PB-SR mu CT could be used as a reliable imaging technique and offers a novel platform for tracking cavity formation and morphological changes in an experimental animal model of PTS. |
| WOS关键词 | SPINAL-CORD-INJURY ; FLUID-FLOW ; AUSTRALIAN SYNCHROTRON ; COMPUTED-TOMOGRAPHY ; MEDICAL BEAMLINE ; MICRO-TOMOGRAPHY ; ANIMAL-MODEL ; MICROSTRUCTURE ; VISUALIZATION ; DEGENERATION |
| 资助项目 | National Natural Science Foundation of China[81301542] ; National Natural Science Foundation of China[81371956] ; National Natural Science Foundation of China[81171698] ; National Natural Science Foundation of China[61772556] ; Central South University[2016zzts123] ; Hunan Provincial Innovation Foundation[CX2015B060] |
| WOS研究方向 | Instruments & Instrumentation ; Optics ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000414172900011 |
| 出版者 | INT UNION CRYSTALLOGRAPHY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272430]  |
| 专题 | 分子影像中心（筹） |
| 通讯作者 | Wu, Tianding |
| 作者单位 | 1.Key Lab Organ Injury Aging & Regenerat Med Hunan, Changsha 410008, Hunan, Peoples R China; 2.Cent S Univ, Sch Informat Sci & Engn, Changsha 410008, Hunan, Peoples R China; 3.Cent S Univ, Xiangya Hosp, Res Ctr Sports Med, Dept Sports Med, Changsha 410008, Hunan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 5.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha 410008, Hunan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liao, Shenghui,Ni, Shuangfei,Cao, Yong,et al. The 3D characteristics of post-traumatic syringomyelia in a rat model: a propagation-based synchrotron radiation microtomography study[J]. JOURNAL OF SYNCHROTRON RADIATION,2017,24:1218-1225. |
| APA | Liao, Shenghui.,Ni, Shuangfei.,Cao, Yong.,Yin, Xianzhen.,Wu, Tianding.,...&Lang, Ye.(2017).The 3D characteristics of post-traumatic syringomyelia in a rat model: a propagation-based synchrotron radiation microtomography study.JOURNAL OF SYNCHROTRON RADIATION,24,1218-1225. |
| MLA | Liao, Shenghui,et al."The 3D characteristics of post-traumatic syringomyelia in a rat model: a propagation-based synchrotron radiation microtomography study".JOURNAL OF SYNCHROTRON RADIATION 24(2017):1218-1225. |
入库方式： OAI收割
来源：上海药物研究所
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