Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2
文献类型：期刊论文
| 作者 | Qian, Hai-Yan2; Wang, Zhi-Long1; Pan, You-Lu2; Chen, Li-Li2 ; Xie, Xin1; Chen, Jian-Zhong2
|
| 刊名 | ACS MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2017-06 |
| 卷号 | 8期号:6页码:678-681 |
| 关键词 | Cannabinoid receptors CB2 agonist structure-activity relationship molecular modeling |
| ISSN号 | 1948-5875 |
| DOI | 10.1021/acsmedchemlett.7b00007 |
| 文献子类 | Article |
| 英文摘要 | Starting from a prototypical structure 1, we describe our efforts to design and obtain novel quinazoline/ pyrimidine-2,4(1H,3H)-diones with high CB2 agonist potency and selectivity as well as improved physicochemical characteristics, mainly hydrophilicity. The most potent and selective CB2 agonists, 8 and 36, in this series were also endowed with lower logP values than that of GW842166X and lead compound 1. These derivatives appear to be promising lead compounds for the development of future CB2 agonists. |
| WOS关键词 | CB2 RECEPTOR ; SELECTIVE LIGANDS ; PHARMACOLOGY ; ANTAGONISTS ; KNOWLEDGE ; PAIN |
| 资助项目 | National Natural Science Foundation of China[30973637] ; National Natural Science Foundation of China[81425024] ; National Natural Science Foundation of China[81473135] ; Ministry of Science and Technology[2014CB541906] ; Zhejiang Technology Office (Qjanjiang Talents Project)[2010R10048] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000403199400016 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272642]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Xie, Xin; Chen, Jian-Zhong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Qian, Hai-Yan,Wang, Zhi-Long,Pan, You-Lu,et al. Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2[J]. ACS MEDICINAL CHEMISTRY LETTERS,2017,8(6):678-681. |
| APA | Qian, Hai-Yan,Wang, Zhi-Long,Pan, You-Lu,Chen, Li-Li,Xie, Xin,&Chen, Jian-Zhong.(2017).Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2.ACS MEDICINAL CHEMISTRY LETTERS,8(6),678-681. |
| MLA | Qian, Hai-Yan,et al."Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2".ACS MEDICINAL CHEMISTRY LETTERS 8.6(2017):678-681. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。