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Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice

文献类型：期刊论文

作者Xue, Xiang2,3; Xiao, Ying2,3; Gong, Likun2; Guan, Shuhong1; Liu, Yongzhen2; Lu, Henglei2; Qi, Xinming2; Zhang, Yunhai2,3; Li, Yan2,3; Wua, Xiongfei2,3
刊名JOURNAL OF ETHNOPHARMACOLOGY
出版日期2008-09-02
卷号119期号:1页码:87-93
关键词oral toxicity Longdan Xieganwan Akebia trifoliate (Thunb.) koidz. Akebia quinata (Thunb.) Decne. Caulis aristolochiae manshuriensis no-observed-adverse-effect level
ISSN号0378-8741
DOI10.1016/j.jep.2008.05.037
文献子类Article
英文摘要Ethnopharmacological relevance: Longdan Xieganwan, which contains Aristolochia species, is a traditional Chinese prescription. It has been used for thousands of years to "enhance liver". However, many cases of Longdan Xieganwan induced nephropathy were reported recently. Aim of the study: This study was designed to compare the possible toxic effects of Longdan Xieganwan and three different Aristolochia species. i.e. Akebia trifoliate (Thunb.) koid (Akebia trifoliate), Akebia quinata (Thunb.) Decne. (Akebia quinata) and Caulis aristolochiae manshuriensis (Aristolochia manshuriensis). Materials and methods: Mice were orally administered these drugs for 28 days. Clinical signs, body weights, serum biochemistry, organ weights and histopathology were examined. Results: Significantly decreased body weights and obvious nephropathy were noticed in the Aristolochia manshuriensis groups at doses higher than 0.24g/kg/d. A few endothelial cell degenerations in renal glomerulus were observed in the Akebia trifoliate group at a high-dose of 2.00 g/kg/d. No significant changes were observed in the other groups. Conclusions: The no-observed-adverse-effect levels (NOAELs) for Aristolochia manshuriensis, Akebia trifoliate, Akebia quinata and Longdan Xieganwan in this study for mice were 0.06 g/kg/d, 0.40 g/kg/d, higher than 3.00 g/kg/d and higher than 10.00 g/kg/d, which were equivalent to 0.25 times, 5 times, 25 times and 10 times of normal human dose in clinical prescription, respectively. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
WOS关键词CHINESE HERBS ; NEPHROPATHY ; ACIDS ; FIBROSIS ; LESSONS
资助项目National Grand Fundamental Research 973 Program of China[2006CB504700]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000259336600013
出版者ELSEVIER IRELAND LTD
源URL[http://119.78.100.183/handle/2S10ELR8/272813]  
专题药物安全性评价中心
通讯作者Ren, Jin
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Ctr Drug Safety & Evaluat, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Xue, Xiang,Xiao, Ying,Gong, Likun,et al. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2008,119(1):87-93.
APA Xue, Xiang.,Xiao, Ying.,Gong, Likun.,Guan, Shuhong.,Liu, Yongzhen.,...&Ren, Jin.(2008).Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice.JOURNAL OF ETHNOPHARMACOLOGY,119(1),87-93.
MLA Xue, Xiang,et al."Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice".JOURNAL OF ETHNOPHARMACOLOGY 119.1(2008):87-93.

入库方式： OAI收割

来源：上海药物研究所

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