Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region
文献类型：期刊论文
| 作者 | Li, Ting1,2; Yu, Xiu-Ju2; Zhang, Guang-Yi1,2 |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2008-06-11 |
| 卷号 | 582期号:13页码:1894-1900 |
| 关键词 | HPK1 cerebral ischemia Src N-methyl-D-aspartate receptor (NMDAR) neuroprotection c-jun NH2-terminal kinase (JNK) |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/j.febslet.2008.05.009 |
| 文献子类 | Article |
| 英文摘要 | Hematopoietic progenitor kinase 1 (HPK1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. We recently reported that HPK1 is involved in c-Jun NH2-terminal kinase (JNK) signaling pathway by sequential activation of MLK3-MWK7-JNK3 after cerebral ischemia. Here, we used 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo [3,4-d] pyrimidine (PP2) and MK801 to investigate the events upstream of HPK1 in ischemic brain injury. Immunoprecipitation and immunoblot results showed that PP2 and MK801 significantly decreased the activation of Src, HPK1, MLK3, JNK3 and c-Jun, respectively, during ischemia/reperfusion. Histology and TUNEL staining showed PP2 or MK801 protects against neuron death after brain ischemia. We speculate that this unique signaling pathway through the tyrosine phosphorylation of HPK1 promotes ischemic brain injury by activated Src via N-methyl-D-aspartate receptor and, ultimately, the activation of the MLK3-MKK7-JNK3 pathway after cerebral ischemia. (c) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. |
| WOS关键词 | HEMATOPOIETIC PROGENITOR KINASE-1 ; N-TERMINAL KINASE ; ADAPTER PROTEINS ; INHIBITOR ; RECEPTORS ; PATHWAY ; CASCADE ; POTENT ; NR2A ; CRK |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000257073800019 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272891]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Zhang, Guang-Yi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200231, Peoples R China 2.Xuzhou Med Coll, Jiangsu Key Lab Brain Dis Bioinformat, Res Ctr Biochem & Mol Biol, Jiangsu 221002, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Ting,Yu, Xiu-Ju,Zhang, Guang-Yi. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region[J]. FEBS LETTERS,2008,582(13):1894-1900. |
| APA | Li, Ting,Yu, Xiu-Ju,&Zhang, Guang-Yi.(2008).Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region.FEBS LETTERS,582(13),1894-1900. |
| MLA | Li, Ting,et al."Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region".FEBS LETTERS 582.13(2008):1894-1900. |
入库方式： OAI收割
来源：上海药物研究所
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