Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression
文献类型：期刊论文
| 作者 | Li, Ting1,2; Han, Dong2; Chen, Juan2; Yu, Xiuju2; Zhang, Guang-Yi1,2 |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2008-04-16 |
| 卷号 | 19期号:6页码:647-651 |
| 关键词 | antisense oligodeoxynucleotides cerebral ischemia c-Jun NH2-terminal kinase hematopietic progenitor kinase 1 |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/WNR.0b013e3282f942a8 |
| 文献子类 | Article |
| 英文摘要 | In this study, we investigated the role of hematopietic progenitor kinase 1 (HPK1) in delayed neuronal damage after cerebral ischemia and the possible regulatory mechanisms of this event. Our data show that tyrosine phosphorylation of HPK1 was significantly increased at 6 h of ischemic-reperfusion compared with sham control. The increase in p-HPK1, p-MLK3, p-MKK7, and p-JNK3 was attenuated by HPK1 antisense oligodeoxynucleotides intra-cerebroventricular infusion, but not MS-ODNs or vehicle. Intra-cerebroventricular infusion of antisense oligodeoxynucleotides also increased the number of surviving pyramidal neurons, whereas MS-ODNs or vehicle (TE) groups had no effects. These results indicate that knockdown of HPK1 expression provides neuroprotection through downregulation activation of the MLK3-MKK7-JNK3 pathway following cerebral ischemia in the rat hippocampus CA1 subfield. |
| WOS关键词 | HEMATOPOIETIC PROGENITOR KINASE-1 ; N-TERMINAL KINASE ; RAT HIPPOCAMPUS ; CEREBRAL-ISCHEMIA ; PROTEIN-KINASE ; MIXED LINEAGE ; ACTIVATION ; HPK1 ; JNK3 ; APOPTOSIS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000255301300009 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272938]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Zhang, Guang-Yi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Jiangsu Key Lab Brain Dis Bioinormat, Jiangsu 221002, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Ting,Han, Dong,Chen, Juan,et al. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression[J]. NEUROREPORT,2008,19(6):647-651. |
| APA | Li, Ting,Han, Dong,Chen, Juan,Yu, Xiuju,&Zhang, Guang-Yi.(2008).Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression.NEUROREPORT,19(6),647-651. |
| MLA | Li, Ting,et al."Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression".NEUROREPORT 19.6(2008):647-651. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。