Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1 beta
文献类型：期刊论文
| 作者 | Ma, Xue-Qin; Zhang, Hua-Jie; Zhang, Ya-Hui; Chen, Yi-Hua; Wu, Fang; Du, Jun-Qing; Yu, Hai-Ping; Zhou, Zhong-Liang; Li, Jing-Ya ; Nan, Fa-Jun
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| 刊名 | BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
 |
| 出版日期 | 2007-02 |
| 卷号 | 85期号:1页码:56-65 |
| 关键词 | caspase-1 inhibitor slow binding irreversible IL-1 beta processing |
| ISSN号 | 0829-8211 |
| DOI | 10.1139/O06-149 |
| 文献子类 | Article |
| 英文摘要 | Caspase-1, the most efficient enzyme in processing the proinflammatory cytokines interleukin 1 beta and interleukin 18 in humans, is associated with inflammatory diseases such as rheumatoid arthritis, osteoarthritis, and some neuronal diseases. We previously reported that isoquinoline-1,3,4-trione and its derivatives are novel caspase-3 inhibitors that could attenuate apoptosis in vitro and in vivo. Here we report a novel derivative of isoquinoline-1,3,4-trione that is highly potent in inhibiting caspase-1 activity in an irreversible and slow-binding manner, thus inhibiting cellular caspase-1 activity and the maturation of interleukin 1 beta in U-937 cells. |
| WOS关键词 | TRAUMATIC BRAIN-INJURY ; TRANSGENIC MOUSE MODEL ; CONVERTING-ENZYME ; INFLAMMATORY CASPASES ; NEURONAL DEATH ; APOPTOSIS ; ACTIVATION ; PROLIFERATION ; FUNCTIONALITY ; PANCREATITIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245407200006 |
| 出版者 | NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273332]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Nan, Fa-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.E China Normal Univ, Acad Life Sci, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xue-Qin,Zhang, Hua-Jie,Zhang, Ya-Hui,et al. Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1 beta[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,2007,85(1):56-65. |
| APA | Ma, Xue-Qin.,Zhang, Hua-Jie.,Zhang, Ya-Hui.,Chen, Yi-Hua.,Wu, Fang.,...&Li, Jia.(2007).Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1 beta.BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,85(1),56-65. |
| MLA | Ma, Xue-Qin,et al."Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1 beta".BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 85.1(2007):56-65. |
入库方式： OAI收割
来源：上海药物研究所
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