Isoquinoline-1,3,4-trione and its derivatives attenuate beta-amyloid-induced apoptosis of neuronal cells
文献类型：期刊论文
| 作者 | Zhang, Ya-Hui; Zhang, Hua-Jie; Wu, Fang; Chen, Yi-Hua; Ma, Xue-Qin; Du, Jun-Qin; Zhou, Zhong-Liang; Li, Jing-Ya ; Nan, Fa-Jun; Li, Jia
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| 刊名 | FEBS JOURNAL
 |
| 出版日期 | 2006-11 |
| 卷号 | 273期号:21页码:4842-4852 |
| 关键词 | attenuate apoptosis beta-amyloid caspase-3 inhibitor irreversible neuronal cell |
| ISSN号 | 1742-464X |
| DOI | 10.1111/j.1742-4658.2006.05483.x |
| 文献子类 | Article |
| 英文摘要 | Caspase-3 is a programmed cell death protease involved in neuronal apoptosis during physiological development and under pathological conditions. It is a promising therapeutic target for treatment of neurodegenerative diseases. We reported previously that isoquinoline-1,3,4-trione and its derivatives inhibit caspase-3. In this report, we validate isoquinoline-1,3,4-trione and its derivatives as potent, selective, irreversible, slow-binding and pan-caspase inhibitors. Furthermore, we show that these inhibitors attenuated apoptosis induced by beta-amyloid(25-35) in PC12 cells and primary neuronal cells. |
| WOS关键词 | TRAUMATIC BRAIN-INJURY ; CASPASE INHIBITOR ; PRECURSOR PROTEIN ; PEPTIDE ; ACTIVATION ; CLEAVAGE ; POTENT ; INVOLVEMENT ; SURVIVAL ; DISEASE |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000241343900004 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273457]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Nan, Fa-Jun |
| 作者单位 | 1.E China Normal Univ, Acad Life Sci, Shanghai 200062, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ya-Hui,Zhang, Hua-Jie,Wu, Fang,et al. Isoquinoline-1,3,4-trione and its derivatives attenuate beta-amyloid-induced apoptosis of neuronal cells[J]. FEBS JOURNAL,2006,273(21):4842-4852. |
| APA | Zhang, Ya-Hui.,Zhang, Hua-Jie.,Wu, Fang.,Chen, Yi-Hua.,Ma, Xue-Qin.,...&Li, Jia.(2006).Isoquinoline-1,3,4-trione and its derivatives attenuate beta-amyloid-induced apoptosis of neuronal cells.FEBS JOURNAL,273(21),4842-4852. |
| MLA | Zhang, Ya-Hui,et al."Isoquinoline-1,3,4-trione and its derivatives attenuate beta-amyloid-induced apoptosis of neuronal cells".FEBS JOURNAL 273.21(2006):4842-4852. |
入库方式： OAI收割
来源：上海药物研究所
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