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Facile synthesis of versatile functionalized amino caprolactams using RCM reactions of alpha-amino acrylamide

文献类型：期刊论文

作者Liu, G; Tai, WY; Li, YL; Nan, FJ
刊名TETRAHEDRON LETTERS
出版日期2006-05-08
卷号47期号:19页码:3295-3298
关键词ring-closing metathesis functionalized lactams natural products alpha-amino acrylamide alpha-amino alpha,beta-unsaturated caprolactams
ISSN号0040-4039
DOI10.1016/j.tetlet.2006.03.022
文献子类Article
英文摘要We report an efficient synthetic methodology allowing access to functionalized alpha-amino caprolactams using ring-closing metathesis (RCM). A very high tolerance of alpha-amino acrylamide RCM precursors toward functional groups is demonstrated. The synthetic pathway is facile, and can be extended to prepare a variety of substituted amino caprolactams in good to excellent yields. These compounds serve as versatile building blocks for the synthesis of some important natural products and their analogues. (c) 2006 Elsevier Ltd. All rights reserved.
WOS关键词ORIENTED ORGANIC-SYNTHESIS ; RING-CLOSING METATHESIS ; BENGAMIDE-B ; STEREOSELECTIVE-SYNTHESIS ; ANTIMYCOBACTERIAL AGENTS ; ANALOGS ; INHIBITORS ; ACID
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000236986000024
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/273600]  
专题国家新药筛选中心
通讯作者Nan, FJ
作者单位1.Lanzhou Univ, Inst Organ Chem, Lanzhou 730000, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
3.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med,Chinese Natl Ctr Drug Scree, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liu, G,Tai, WY,Li, YL,et al. Facile synthesis of versatile functionalized amino caprolactams using RCM reactions of alpha-amino acrylamide[J]. TETRAHEDRON LETTERS,2006,47(19):3295-3298.
APA Liu, G,Tai, WY,Li, YL,&Nan, FJ.(2006).Facile synthesis of versatile functionalized amino caprolactams using RCM reactions of alpha-amino acrylamide.TETRAHEDRON LETTERS,47(19),3295-3298.
MLA Liu, G,et al."Facile synthesis of versatile functionalized amino caprolactams using RCM reactions of alpha-amino acrylamide".TETRAHEDRON LETTERS 47.19(2006):3295-3298.

入库方式： OAI收割

来源：上海药物研究所

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