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Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

文献类型：期刊论文

作者Huang, WG; Li, JY; Zhang, W; Zhou, YY; Xie, CM; Luo, Y; Li, YF; Wang, JL; Li, J; Lu, W
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2006-04-01
卷号16期号:7页码:1905-1908
关键词miltirone Cdc25 phosphatases cancer
ISSN号0960-894X
DOI10.1016/j.bmcl.2005.12.080
文献子类Article
英文摘要Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range. (C) 2006 Elsevier Ltd. All rights reserved.
WOS关键词SPECIFICITY PROTEIN PHOSPHATASE ; HUMAN COLORECTAL-CARCINOMA ; SMALL-MOLECULE INHIBITORS ; BIOLOGICAL EVALUATION ; TYROSINE PHOSPHATASES ; SALVIA-MILTIORRHIZA ; IDENTIFICATION ; DERIVATIVES ; TANSHINONES ; EXPRESSION
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000236402500028
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/273623]  
专题国家新药筛选中心
通讯作者Li, J
作者单位1.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
2.Chinese Acad Sci, Grad Sch, Natl Ctr Drugs Screening, Shanghai Inst Mat Med,SIBS, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Huang, WG,Li, JY,Zhang, W,et al. Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(7):1905-1908.
APA Huang, WG.,Li, JY.,Zhang, W.,Zhou, YY.,Xie, CM.,...&Lu, W.(2006).Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(7),1905-1908.
MLA Huang, WG,et al."Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.7(2006):1905-1908.

入库方式： OAI收割

来源：上海药物研究所

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