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Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids

文献类型：期刊论文

作者Ma, DW; Jiang, YW; Chen, FP; Gong, LK; Ding, K; Xu, Y; Wang, RX; Ge, AH; Ren, J; Li, JY
刊名JOURNAL OF MEDICINAL CHEMISTRY
出版日期2006-01-26
卷号49期号:2页码:456-458
ISSN号0022-2623
DOI10.1021/jm051101g
文献子类Article
英文摘要The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of gamma-keto carboxylic acids are described. Among nine MNIP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and - 12 with IC50 values between 0.20 and 1.51 mu M, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema.
WOS关键词SMOKE-INDUCED EMPHYSEMA ; STRUCTURE-BASED DESIGN ; POTENT ; ELASTASE ; MMP-13
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000234836200005
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/273686]  
专题药物安全性评价中心
通讯作者Ma, DW
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714		 Ma, DW,Jiang, YW,Chen, FP,et al. Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids[J]. JOURNAL OF MEDICINAL CHEMISTRY,2006,49(2):456-458.
APA Ma, DW.,Jiang, YW.,Chen, FP.,Gong, LK.,Ding, K.,...&Ye, Q.(2006).Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids.JOURNAL OF MEDICINAL CHEMISTRY,49(2),456-458.
MLA Ma, DW,et al."Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids".JOURNAL OF MEDICINAL CHEMISTRY 49.2(2006):456-458.

入库方式： OAI收割

来源：上海药物研究所

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