Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent
文献类型：期刊论文
| 作者 | Luo, QL; Li, JY ; Chen, LL; Li, J; Ye, QZ; Nan, FJ
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2005-02-01 |
| 卷号 | 15期号:3页码:639-644 |
| 关键词 | type I MetAPs inhibitors |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2004.11.035 |
| 文献子类 | Article |
| 英文摘要 | Systematic SAR studies on the pyridine ring 3-substituent of PCAT, an inhibitor of EcMetAP1 and ScMetAP1, revealed that 3-substituents have different selectivity for EcMetAP1 and ScMetAP1. The selective inhibitors of type I MetAP are useful tools for investigating the detailed interactions between the enzymes and their inhibitors. In addition, these findings provide useful information for the design and discovery of more potent inhibitors of type I MetAPs. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | METHIONINE AMINOPEPTIDASE ; ESCHERICHIA-COLI ; SACCHAROMYCES-CEREVISIAE ; ANGIOGENESIS INHIBITORS ; PROTEINS ; GENE |
| 资助项目 | NCRR NIH HHS[1P20 RR15563] ; NIAAA NIH HHS[AA234011] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000226935700030 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273918]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Ye, QZ |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med,Chinese Natl Ctr Drug Scree, Shanghai 201203, Peoples R China 2.Chongqing Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China 3.Univ Kansas, High Throughput Screening Lab, Lawrence, KS 66047 USA |
| 推荐引用方式 GB/T 7714 | Luo, QL,Li, JY,Chen, LL,et al. Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(3):639-644. |
| APA | Luo, QL,Li, JY,Chen, LL,Li, J,Ye, QZ,&Nan, FJ.(2005).Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,15(3),639-644. |
| MLA | Luo, QL,et al."Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15.3(2005):639-644. |
入库方式： OAI收割
来源：上海药物研究所
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