Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes
文献类型：期刊论文
| 作者 | Cui, YM; Li, JY ; Chen, LL; Li, J; Ye, QZ; Nan, FJ
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2004-06-01 |
| 卷号 | 12期号:11页码:2853-2861 |
| 关键词 | methionine aminopeptidases chromogenic thiopeptolide substrates |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2004.03.044 |
| 文献子类 | Article |
| 英文摘要 | Twenty one chromogenic thiopeptolide substrates were designed and synthesized as the active site probes and analyzed with each S1 site of mutant residues and enzymes of wild-type MetAPls. The preliminary enzymatic experiments indicate that cysteine 70 or 202, at either Escherichia coli or human MetAPl, played a crucial role in the methionine hydrolysis. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | METHIONINE AMINOPEPTIDASE ; ESCHERICHIA-COLI |
| 资助项目 | NCRR NIH HHS[1 P20 RR15563] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000221676700005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274066]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Nan, FJ |
| 作者单位 | 1.Univ Kansas, High Throughput Screening Lab, Lawrence, KS 66047 USA 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, YM,Li, JY,Chen, LL,et al. Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2004,12(11):2853-2861. |
| APA | Cui, YM,Li, JY,Chen, LL,Li, J,Ye, QZ,&Nan, FJ.(2004).Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes.BIOORGANIC & MEDICINAL CHEMISTRY,12(11),2853-2861. |
| MLA | Cui, YM,et al."Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes".BIOORGANIC & MEDICINAL CHEMISTRY 12.11(2004):2853-2861. |
入库方式： OAI收割
来源：上海药物研究所
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