Inhibition of regrowth of prostatic glandular cells by epristeride
文献类型：期刊论文
| 作者 | Qian, LH; Wang, XL ; Tu, ZH
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2001-09 |
| 卷号 | 22期号:9页码:847-850 |
| 关键词 | epristeride prostate castration immunohistochemistry |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To evaluate the ability of epristeride to inhibit the prostatic glandular regrowth. METHODS: Normal rats were castrated. Testosterone was injected to induce the regrowth of glandular cells. HE staining was performed. The height of the glandular epithelium and the acinar luminal areas were determined, and dihydrotestosterone ( DHT) was detected by immunohistochemistry. RESULTS : Both the height and the acinar luminal areas were reduced by 48 % and 55 % in epristeride-treated group compared with control group respectively. The staining of DHT was comparatively strong in the control group. After 30-d of treatment, it tamed much weaker. CONCLUSION: The regrowth of glandular cells was inhibited by epristeride via declining of the DHT concentration in the rat prostate. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:515895 |
| WOS记录号 | WOS:000171146200015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274451]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Tu, ZH |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, LH,Wang, XL,Tu, ZH. Inhibition of regrowth of prostatic glandular cells by epristeride[J]. ACTA PHARMACOLOGICA SINICA,2001,22(9):847-850. |
| APA | Qian, LH,Wang, XL,&Tu, ZH.(2001).Inhibition of regrowth of prostatic glandular cells by epristeride.ACTA PHARMACOLOGICA SINICA,22(9),847-850. |
| MLA | Qian, LH,et al."Inhibition of regrowth of prostatic glandular cells by epristeride".ACTA PHARMACOLOGICA SINICA 22.9(2001):847-850. |
入库方式： OAI收割
来源：上海药物研究所
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