Supraspinal D-2 receptor involved in antinociception induced by l-tetrahydropalmatine
文献类型：期刊论文
| 作者 | Hu, JY; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-08 |
| 卷号 | 20期号:8页码:715-719 |
| 关键词 | tetrahydropalmatine dopamine receptors quinpirole spiperone SKF38393 Sch-23390 naloxone antinociception non-narcotic analgesics |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the role of dopamine (DA) receptors in ;-tetrahydropalmatine (l-THP)-induced antinociception. METHODS: The intraperitoneal tip) and intrathecal (ith) injections were used to give the drugs. The tail-flick test was used to assess the nociceptive threshold of rats. RESULTS: By ip injection, l-THP (10, 20, 40 mg . kg(-1)) as well as D-2 receptor antagonist spiperone (1, 2, 3 mg . kg(-1)) produced dose-dependent antinociceptive effects on the nociception of rats, while D-2 receptor agonist quinpirole, D-1 receptor agonist SKF38393, and D-1 receptor antagonist Sch-23390 showed no antinociception. Moreover, l-THP- or spiperone-induced antinociception was markedly attenuated by quinpirole (2, 3 mg . kg(-1)) but not SKF38393 or naloxone. On the other hand, ith quinpirole (20, 30, 40 mu g . kg(-1)) also induced a dose-dependent antinociception, while ith I-THP, spiperone, SKF38393, and Sch-23390 did not exhibit any antinociception. Furthermore, ith spiperone (20, 30, 40 Ccg.kg(-1)) but not Sch-23390 dose-dependently antagonised the antinociception induced by quinpirole. l-THP (ith, 100, 200, 300 mu g.kg(-1)) also dramatically attenuated the quinpirole-induced antinociception with a dose-dependent relationship. CONCLUSION: Activating the spinal D-2 receptor or blocking the supraspinal D-2 receptor produces antinociception. D-1 receptor might be not directly involved in the antinociception. l-THP (as a D-2 antagonist) as well as spiperone produces antinociception via blocking the supraspinal D-2 receptor. |
| WOS关键词 | DOPAMINERGIC AGENTS ; RAT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:845938 |
| WOS记录号 | WOS:000081902700008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274709]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, JY,Jin, GZ. Supraspinal D-2 receptor involved in antinociception induced by l-tetrahydropalmatine[J]. ACTA PHARMACOLOGICA SINICA,1999,20(8):715-719. |
| APA | Hu, JY,&Jin, GZ.(1999).Supraspinal D-2 receptor involved in antinociception induced by l-tetrahydropalmatine.ACTA PHARMACOLOGICA SINICA,20(8),715-719. |
| MLA | Hu, JY,et al."Supraspinal D-2 receptor involved in antinociception induced by l-tetrahydropalmatine".ACTA PHARMACOLOGICA SINICA 20.8(1999):715-719. |
入库方式： OAI收割
来源：上海药物研究所
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