Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain
文献类型：期刊论文
| 作者 | Hu, JY; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-03 |
| 卷号 | 20期号:3页码:193-200 |
| 关键词 | tetrahydropalmatine tetrahydroprotoberberines stepholidine protooncogene proteins c-fos formaldehyde immunohistochemistry quinpirole spiperone |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs. METHODS: The pain response to Sprague Dawley rats was induced with formalin injected sc into the plantar surface of the right hindpaw. Fos protein expression in brain and spinal cord was investigated with immunohistochemistry. The numbers of Fos-like immunoreactive (FLI) neurons were counted with Leica Q570 image analyzer. RESULTS: In the groups of THP analogs and D-2 antagonist spiperone, FLI: neurons induced by intraperitoneal tip) injection of THP analogs and spiperone were mainly located in the striatum and accumbens nucleus, and a few FLI neurons were also in sensorimotor cortex. In the D-1 antagonist, D1 agonist, D2 agonist, saline and vehicle groups, FLI neurons were seldom seen in the striatum and accumbens nucleus. Moreover, the Fos protein expression induced by I-THP and spiperone could be prevented by the pretreatment of the D-2 agonist quinpirole but not D-1 agonist SKF38393. Ln the formalin-pain group, FLI neurons were mainly distributed in ascending pain afferent system (APAS) and descending pain modulation system (DPMS). Following ip THP analogs, however, the numbers of FLI neurons induced by formalin-pain in the APAS, such as dorsal horn (mainly laminae I, II, IV - VI were markedly decreased, while the numbers of FLI neurons in the DPMS, such as periaqueductal gray ( FAG) and reticular paragigantocellular lateral nucleus (RPLN) were significantly increased. CONCLUSION: THP analogs enhanced the activity of brainstem DPMS by the blockade of D-2 receptors in the striatum and accumbens nucleus, and sequentially inhibited the inputs of peripheral pain afferent message in spinal cord level. |
| WOS关键词 | SPINAL-CORD ; NERVOUS-SYSTEM ; C-FOS ; NEURONS ; BRAIN ; RATS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000079115400001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274745]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, JY,Jin, GZ. Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain[J]. ACTA PHARMACOLOGICA SINICA,1999,20(3):193-200. |
| APA | Hu, JY,&Jin, GZ.(1999).Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain.ACTA PHARMACOLOGICA SINICA,20(3),193-200. |
| MLA | Hu, JY,et al."Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain".ACTA PHARMACOLOGICA SINICA 20.3(1999):193-200. |
入库方式： OAI收割
来源：上海药物研究所
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