D-1/D-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion
文献类型：期刊论文
| 作者 | Guo, X; Zou, LL; Jin, GZ
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 1998-05-29 |
| 卷号 | 63期号:1页码:PL7-PL12 |
| 关键词 | spiperone SCH23390 radioligand assay D-1/D-2 interaction 6-hydroxydopamine |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/S0024-3205(98)00239-2 |
| 文献子类 | Article |
| 英文摘要 | D-1/D-2 interaction in rat striatum was investigated by examining the effect of the D-2 antagonist spiperone on the binding of [H-3]SCH23390 to D-1 dopamine (DA) receptors. In the presence of endogenous DA, spiperone blocked D-2 receptors, then caused the increase of the binding of [H-3]SCH23390 in rat striatal homogenate. After the 6-hydroxydopamine (6-OHDA) lesion, the increase was not found even if in the addition of exogenous DA. The results suggest that the D-2 antagonist can modify the interaction between endogenous DA and D-1 receptors labeled with [H-3]SCH23390, while 6-OHDA lesion may change the state of D-1/D-2 interaction operating at the receptor level. (C) 1998 Elsevier Science Inc. |
| WOS关键词 | D-2 RECEPTORS ; STIMULATION ; ANTAGONISTS ; AGONISTS ; BRAIN ; RATS ; LINK ; D1 |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074036000010 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274836]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, X,Zou, LL,Jin, GZ. D-1/D-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion[J]. LIFE SCIENCES,1998,63(1):PL7-PL12. |
| APA | Guo, X,Zou, LL,&Jin, GZ.(1998).D-1/D-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion.LIFE SCIENCES,63(1),PL7-PL12. |
| MLA | Guo, X,et al."D-1/D-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion".LIFE SCIENCES 63.1(1998):PL7-PL12. |
入库方式： OAI收割
来源：上海药物研究所
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