Effect of L-4-oxalysine on alpha-fetoprotein gene expression in human BEL-7404 hepatoma cells
文献类型：期刊论文
| 作者 | Wang, XW; Xu, B
|
| 刊名 | ASIA PACIFIC JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1997-06 |
| 卷号 | 12期号:1-2页码:37-40 |
| 关键词 | L-4-oxalysine alpha-fetoprotein gene expression hepatoma BEL-7404 cultured tumor cells |
| ISSN号 | 0217-9687 |
| 文献子类 | Article |
| 英文摘要 | Influence of L-4-oxalysine (OXL) on alpha-fetoprotein (AFP) gene expression was investigated by in vitro experiments. Exposure of exponentially growing BEL-7404 human hepatoma cells to OXL 6.3-100 mg L-1 for 48 h resulted in an obvious decrease of AFP content in culture media with the inhibition percentages of about 32%-72% as measured by enzyme-linked immunosorbent assay (ELISA) technique. But the same concentrations of OXL did not affect albumin level in culture media. In the presence of 25-100 mg L-1 of OXL, the growth of hepatoma cells was significantly suppressed. On the other hand, after treatment of hepatoma cells with OXL 25 and 50 mg L-1, respectively for 48 h, AFP content in hepatoma cells was also markedly lowered as assessed with the avidin-biotin-peroxidase complex (ABC) method. The results indicated that OXL specifically inhibited AFP gene expression in human BEL-7404 hepatoma cells, which might contribute to its anti-hepatoma activities. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997YC96100007 |
| 出版者 | SINGAPORE UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274904]  |
| 专题 | 院士及顾问专家 药物安全性评价中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Wang, XW,Xu, B. Effect of L-4-oxalysine on alpha-fetoprotein gene expression in human BEL-7404 hepatoma cells[J]. ASIA PACIFIC JOURNAL OF PHARMACOLOGY,1997,12(1-2):37-40. |
| APA | Wang, XW,&Xu, B.(1997).Effect of L-4-oxalysine on alpha-fetoprotein gene expression in human BEL-7404 hepatoma cells.ASIA PACIFIC JOURNAL OF PHARMACOLOGY,12(1-2),37-40. |
| MLA | Wang, XW,et al."Effect of L-4-oxalysine on alpha-fetoprotein gene expression in human BEL-7404 hepatoma cells".ASIA PACIFIC JOURNAL OF PHARMACOLOGY 12.1-2(1997):37-40. |
入库方式： OAI收割
来源：上海药物研究所
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