Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo
文献类型：期刊论文
| 作者 | Lou, YJ; Ding, GS ; Tu, ZH
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1996-01 |
| 卷号 | 17期号:1页码:52-54 |
| 关键词 | aspinin teratogens blastocyst embryo transfer fetal development drug-induced abnormalities |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To explore the relationship between drug-induced blastopathies and post-implantation embryotoxicity or developmental defects. METHODS: Pregnant rats on d 3 were given intragastrically aspirin (0.25, 0.5, and 1 g . kg(-1)). On d 4, the blastocysts were transferred into the uterine horns of pseudopregnant rats (made by mating with male rats which had been given intragastrically 3-chloro-1, 2-propanediol 5 mg . kg(-1) for 5 d). Uterine contents were examined at term. RESULTS: The frequency of blastocysts with morphological alterations (FBMA) was increased on d 4 of gestation. The implantation rate was lower than that of the controls. A dose-related increase in resorption (55.2 %, 69.5 %, and 85.2 %) and malformation rate (3.8 %, 44.4 %, and 25 %), and decrease in viability rate of fetuses (44.8 %, 30.5 %, and 14.8 %) were observed in test groups with correlations to FBMA. CONCLUTION: Embryotoxicity and fetal malformations were induced by treatment of aspirin before implantation in a dose-dependent manner. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:339692 |
| WOS记录号 | WOS:A1996TQ30000013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275011]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Lou, YJ,Ding, GS,Tu, ZH. Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo[J]. ACTA PHARMACOLOGICA SINICA,1996,17(1):52-54. |
| APA | Lou, YJ,Ding, GS,&Tu, ZH.(1996).Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo.ACTA PHARMACOLOGICA SINICA,17(1),52-54. |
| MLA | Lou, YJ,et al."Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo".ACTA PHARMACOLOGICA SINICA 17.1(1996):52-54. |
入库方式： OAI收割
来源：上海药物研究所
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