(-)-STEPHOLIDINE ANTAGONIZES THE INHIBITION BY D-2 RECEPTOR AGONISTS ON SYNAPTOSOMAL TYROSINE HYDROYLASE IN RAT CORPUS STRIATUM
文献类型：期刊论文
| 作者 | HU, G; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-07 |
| 卷号 | 16期号:4页码:376-379 |
| 关键词 | BERBINES (-)-STEPHOLIDINE SPIPERONE FEEDBACK REGULATION DOPAMINERGIC AGENTS TYROSINE HYDROXYLASE CORPUS STRIATUM SYNAPTOSOMES |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To evaluate the action of (-)-stepholidine (SPD), a novel dopamine (DA) receptor antagonist, on inhibition by presynaptic D-2 receptor agonists on the activity of synaptosomal tyrosine hydroxylase (TH) in the striatum. METHOD: The TH activity was measured by HPLC-ECD. RESULTS: The mixed DA receptor agonist apomorphine (Apo 10.4 nmol L(-1)) and selective D-2 receptor agonists N-0437 (0.4 pmol L(-1)) and quinpirole (0.8 mu mol L(-1)) inhibited the activity of TH, while selective D-1 receptor agonist SKF 38393 (0.001-10 mu mol L(-1)) and SPD (1-100 mu mol L(-1)) failed to inhibit the TH activety. The inhibition of N-0437 and quinpirole were antagonized by D-2 receptor antagonist spiperone and SPD. CONCLUSION: The negative feedback regulation of presynaptic DA receptors is mediated via D-2 receptors and SPD is an antagonist on presynaptic D-2 DA receptors. |
| WOS关键词 | L-STEPHOLIDINE ; RELEASE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:288226 |
| WOS记录号 | WOS:A1995RJ09600024 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275040]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | HU, G,JIN, GZ. (-)-STEPHOLIDINE ANTAGONIZES THE INHIBITION BY D-2 RECEPTOR AGONISTS ON SYNAPTOSOMAL TYROSINE HYDROYLASE IN RAT CORPUS STRIATUM[J]. ACTA PHARMACOLOGICA SINICA,1995,16(4):376-379. |
| APA | HU, G,&JIN, GZ.(1995).(-)-STEPHOLIDINE ANTAGONIZES THE INHIBITION BY D-2 RECEPTOR AGONISTS ON SYNAPTOSOMAL TYROSINE HYDROYLASE IN RAT CORPUS STRIATUM.ACTA PHARMACOLOGICA SINICA,16(4),376-379. |
| MLA | HU, G,et al."(-)-STEPHOLIDINE ANTAGONIZES THE INHIBITION BY D-2 RECEPTOR AGONISTS ON SYNAPTOSOMAL TYROSINE HYDROYLASE IN RAT CORPUS STRIATUM".ACTA PHARMACOLOGICA SINICA 16.4(1995):376-379. |
入库方式： OAI收割
来源：上海药物研究所
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