EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS
文献类型：期刊论文
| 作者 | TANG, XC ; XU, H; FENG, J; ZHOU, TX; LIU, JS
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1994-03 |
| 卷号 | 15期号:2页码:107-110 |
| 关键词 | HUPERZINE PHYSOSTIGMINE GALANTHAMINE ISOFLUROPHATE ERYTHROCYTE MEMBRANE CHOLINESTERASE INHIBITORS STRUCTURE-ACTIVITY RELATIONSHIP |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Huperzine (Hup) A and B were first discovered and studied by Chinese. Fourteen analogs of Hup were tested for their anticholinesterase (anti-ChE) activity by colorimetric method using rat erythrocyte membrane and serum as enzyme sources. Hup-A showed the highest anti-AChE potency. The anti-BuChE activity of (-)dihydro and (-) tetrahydro analogs were potent than those of Hup-A. Their anti-AChE activities were comparable to those of physostigmine and galanthamine. Dihydro analog inhibition was of the mixed competitive type with a K-i value of 0.12 mu mol.L(-1). Tetrahydro analog inhibition was of the competitive type with a K-i value of 0.56 mu mol.L(-1). They were different from isoflurophate to bond to AChE in a reversible manner. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1994NA94100003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275104]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | TANG, XC |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHYTOCHEM,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | TANG, XC,XU, H,FENG, J,et al. EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS[J]. ACTA PHARMACOLOGICA SINICA,1994,15(2):107-110. |
| APA | TANG, XC,XU, H,FENG, J,ZHOU, TX,&LIU, JS.(1994).EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS.ACTA PHARMACOLOGICA SINICA,15(2),107-110. |
| MLA | TANG, XC,et al."EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS".ACTA PHARMACOLOGICA SINICA 15.2(1994):107-110. |
入库方式： OAI收割
来源：上海药物研究所
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