INHIBITION OF PHOSPHORYLATION OF HISTONE-H(1) AND HISTONE-H(3) INDUCED BY 10-HYDROXYCAMPTOTHECIN, DNA TOPOISOMERASE-I INHIBITOR, IN MURINE ASCITES HEPATOMA-CELLS
文献类型：期刊论文
| 作者 | LING, YH; XU, B
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1993-11 |
| 卷号 | 14期号:6页码:546-550 |
| 关键词 | 10-HYDROXYCAMPTOTHECIN EXPERIMENTAL LIVER NEOPLASMS CULTURED TUMOR CELLS DNA UNTWISTING PROTEINS HISTONE PHOSPHORYLATION |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Hydroxycamptothecin (HCPT), isolated from Camptotheca acuminata, is a powerful antitumor alkaloid. Previous studies indicated that the molecular target of this agent was DNA topoisomerase I. The present results demonstrated that in vitro treatment of murine ascites hepatoma cells with HCPT resulted in a marked reduction in DNA synthesis and the inhibition of phosphorylation in histone was in a time-dependent manner. Gel electrophoresis found that HCPT had a selectively inhibitory effect on the phosphorylation of histone H-1 and H-3, but less effect on the other kinds of histones. In vivo, HCPT also exhibited a suppressive effect on histone H-1 and H-3 phosphorylation. These data suggested that HCPT-induced cell killing may be, at least in part , associated with the suppression of histone H-1 and H-3 phosphorylation. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:222687 |
| WOS记录号 | WOS:A1993MG89800018 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275117]  |
| 专题 | 院士及顾问专家 药物安全性评价中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL I,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | LING, YH,XU, B. INHIBITION OF PHOSPHORYLATION OF HISTONE-H(1) AND HISTONE-H(3) INDUCED BY 10-HYDROXYCAMPTOTHECIN, DNA TOPOISOMERASE-I INHIBITOR, IN MURINE ASCITES HEPATOMA-CELLS[J]. ACTA PHARMACOLOGICA SINICA,1993,14(6):546-550. |
| APA | LING, YH,&XU, B.(1993).INHIBITION OF PHOSPHORYLATION OF HISTONE-H(1) AND HISTONE-H(3) INDUCED BY 10-HYDROXYCAMPTOTHECIN, DNA TOPOISOMERASE-I INHIBITOR, IN MURINE ASCITES HEPATOMA-CELLS.ACTA PHARMACOLOGICA SINICA,14(6),546-550. |
| MLA | LING, YH,et al."INHIBITION OF PHOSPHORYLATION OF HISTONE-H(1) AND HISTONE-H(3) INDUCED BY 10-HYDROXYCAMPTOTHECIN, DNA TOPOISOMERASE-I INHIBITOR, IN MURINE ASCITES HEPATOMA-CELLS".ACTA PHARMACOLOGICA SINICA 14.6(1993):546-550. |
入库方式： OAI收割
来源：上海药物研究所
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