EFFECTS OF (-)-STEPHOLIDINE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN VENTRAL TEGMENTAL AREA OF RATS
文献类型：期刊论文
| 作者 | SUN, BC; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-09 |
| 卷号 | 13期号:5页码:395-399 |
| 关键词 | BERBINES STEPHOLIDINE TEGMENTUM MESENCEPHALI DOPAMINE RECEPTORS ELECTROPHYSIOLOGY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Extracellular single-unit recording techniques were used to evaluate the effects of (-)-stepholidine (SPD) on the firing activity of ventral tegmental area (VTA) dopamine (DA) neurons. SPD reversed the DA agonist apomorphine (Apo)-induced inhibition of VTA DA cell firing rate (ED50 = 4.9, 4.5-5.3-mu-g . kg-1), and the reversal was more rapid than that of a classic DA antagonist haloperidol (Hal) (ED50 = 11.2, 9.1-13.8-mu-g . kg-1). Pretreatment with SPD or Hal 0.5 mg . kg-1 attenuated Apo-induced inhibition, and SPD rendered the VTA DA cells less sensitive to larger doses of Apo (1024-4096-mu-g . kg-1) than Hal did. Pharmacological analysis indicated that the effects of SPD were mainly mediated through D2 subtype receptors. In addition, SPD increased the firing rate of VTA DA cells, while higher doses (1.4, 0.6-3.3 mg . kg-1) of SPD dramatically inactivated 4 / 6 of the VTA DA cells sampled. This inhibition was considered to be due to depolarization inactivation. These results suggest that SPD is a DA receptor antagonist and can effectively block the D2 autoreceptors located in the VTA DA cells. |
| WOS关键词 | L-STEPHOLIDINE ; TETRAHYDROPROTOBERBERINES ; BEHAVIOR ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:937317 |
| WOS记录号 | WOS:A1992JM88800003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275148]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | SUN, BC,JIN, GZ. EFFECTS OF (-)-STEPHOLIDINE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN VENTRAL TEGMENTAL AREA OF RATS[J]. ACTA PHARMACOLOGICA SINICA,1992,13(5):395-399. |
| APA | SUN, BC,&JIN, GZ.(1992).EFFECTS OF (-)-STEPHOLIDINE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN VENTRAL TEGMENTAL AREA OF RATS.ACTA PHARMACOLOGICA SINICA,13(5),395-399. |
| MLA | SUN, BC,et al."EFFECTS OF (-)-STEPHOLIDINE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN VENTRAL TEGMENTAL AREA OF RATS".ACTA PHARMACOLOGICA SINICA 13.5(1992):395-399. |
入库方式： OAI收割
来源：上海药物研究所
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