INHIBITORY EFFECTS OF HOMOHARRINGTONINE AND HYDROXYCAMPTOTHECIN IN COMBINATION WITH OTHER AGENTS ON CANCER CELL-GROWTH
文献类型：期刊论文
| 作者 | ZHANG, SD; SHEN, LY; XU, B
|
| 刊名 | ASIA PACIFIC JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 1992-09 |
| 卷号 | 7期号:3页码:191-195 |
| 关键词 | HOMOHARRINGTONINE HYDROXYCARNPTOTHECIN DRUG COMBINATION CYTOTOXIC EFFECT |
| ISSN号 | 0217-9687 |
| 文献子类 | Article |
| 英文摘要 | The inhibitory effects of homoharringtonine (HHT) and hydroxycamptothecin (HCPT), used singly or in combination with methotrexate (MTX), adriamycin (ADM), or verapamil (VER), were investigated using a colorimetric assay and a photometric reading method in murine leukemia P388 and hepatoma (HepA) cells. The data analyzed with the computer software of median effect principle suggested that both regimens (HHT + MTX and HCPT + ADM) at a drug exposure time of 4 h could synergically inhibit the growth of tumor cells. The synergism was more obvious as the drug exposure time was extended to 24 h. Moreover, it was noticed that the cytotoxic effect of HHT on P388 cells was significantly augmented by VER at an appropriate drug exposure period. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1992JW73300006 |
| 出版者 | SINGAPORE UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275150]  |
| 专题 | 院士及顾问专家 药物安全性评价中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHANG, SD,SHEN, LY,XU, B. INHIBITORY EFFECTS OF HOMOHARRINGTONINE AND HYDROXYCAMPTOTHECIN IN COMBINATION WITH OTHER AGENTS ON CANCER CELL-GROWTH[J]. ASIA PACIFIC JOURNAL OF PHARMACOLOGY,1992,7(3):191-195. |
| APA | ZHANG, SD,SHEN, LY,&XU, B.(1992).INHIBITORY EFFECTS OF HOMOHARRINGTONINE AND HYDROXYCAMPTOTHECIN IN COMBINATION WITH OTHER AGENTS ON CANCER CELL-GROWTH.ASIA PACIFIC JOURNAL OF PHARMACOLOGY,7(3),191-195. |
| MLA | ZHANG, SD,et al."INHIBITORY EFFECTS OF HOMOHARRINGTONINE AND HYDROXYCAMPTOTHECIN IN COMBINATION WITH OTHER AGENTS ON CANCER CELL-GROWTH".ASIA PACIFIC JOURNAL OF PHARMACOLOGY 7.3(1992):191-195. |
入库方式： OAI收割
来源：上海药物研究所
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