(-)-STEPHOLIDINE - A DOPAMINE RECEPTOR ANTAGONIST SHOWS AGONISTIC EFFECT ON ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE LESIONED RATS
文献类型：期刊论文
| 作者 | HUANG, KX; SUN, BC; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-01 |
| 卷号 | 13期号:1页码:17-22 |
| 关键词 | STEPHOLIDINE BERBINES ROTATION DOPAMINERGIC AGENTS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | (-)-Stepholidine ((-)-SPD), a well demonstrated dopamine (DA) receptor antagonist in normal rats, could markedly induce contralateral rotational behavior in 6-hydroxydopamine (6-OHDA)-lesioned rats. This peculiar behavioral action of (-)-SPD, proposed to be an agonistic action on DA receptors, was further studied in this paper. The rotational behavior challenged by (-)-SPD (4 mg . kg-1, ip) or SKF-39393 (selective D1 agonist) had a gradually progressive process with a long latent period and a plateau response after 56-67 postlesion days. On the contrary, the action of apomorphine (APO) or D2 selective agonist N-0347, had a short latent period and a plateau response after d 21 of postlesion. In the latent period of rotation, (-)-SPD (4 mg . kg-1) was primed by pretreatment of APO (0.2 mg . kg-1, ip). In the period of steady contralateral rotation, a dose-dependent action of (-)-SPD was found in a range of 0.5-8 mg . kg-1 and a linear correlation (r = 0.77, P < 0.01) between the rotation induced by (-)-SPD (4 mg . kg-1) and by APO (0.2 mg . kg-1) was also shown. These results suggest that the agonistic effect of (-)-SPD on rotation behavior in 6-OHDA-lesioned rats resembles that of D1 agonist SKF-38393. Taken together, the dual actions of (-)-SPD, antagonistic on normosensitive DA receptors and agonistic on supersensitive DA receptors, were proposed. |
| WOS关键词 | APOMORPHINE ; SUPERSENSITIVITY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:192012 |
| WOS记录号 | WOS:A1992HA84500003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275182]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | HUANG, KX,SUN, BC,JIN, GZ. (-)-STEPHOLIDINE - A DOPAMINE RECEPTOR ANTAGONIST SHOWS AGONISTIC EFFECT ON ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE LESIONED RATS[J]. ACTA PHARMACOLOGICA SINICA,1992,13(1):17-22. |
| APA | HUANG, KX,SUN, BC,&JIN, GZ.(1992).(-)-STEPHOLIDINE - A DOPAMINE RECEPTOR ANTAGONIST SHOWS AGONISTIC EFFECT ON ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE LESIONED RATS.ACTA PHARMACOLOGICA SINICA,13(1),17-22. |
| MLA | HUANG, KX,et al."(-)-STEPHOLIDINE - A DOPAMINE RECEPTOR ANTAGONIST SHOWS AGONISTIC EFFECT ON ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE LESIONED RATS".ACTA PHARMACOLOGICA SINICA 13.1(1992):17-22. |
入库方式： OAI收割
来源：上海药物研究所
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