beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123
文献类型：期刊论文
| 作者 | Saetang, Praphatsorn1,2; Rukachaisirikul, Vatcharin1,2; Phongpaichit, Souwalak5,6; Sakayaroj, Jariya4; Shi, Xiaofan3; Chen, Jing3 ; Shen, Xu3
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2016-10-13 |
| 卷号 | 72期号:41页码:6421-6427 |
| 关键词 | beta-Resorcylic macrolide Octahydronaphthalene derivative Antifungal activity Cytotoxic activity Protection of pancreatic beta-cells |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2016.08.048 |
| 文献子类 | Article |
| 英文摘要 | Five new metabolites including four beta-resorcylic macrolides 1-4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungus Fusarium sp. PSU-ES123 together with seven known compounds. Their structures were characterized by analysis of the spectroscopic data. The absolute configuration was determined by Mosher's method and circular dichroism spectroscopy. Compound I displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 128 mu g/mL and no cytotoxic activity against noncancerous Vero cell lines. In addition, known zearalenone displayed a protective activity against INS -1 832/13 pancreatic beta-cells by an EC50 value of 6.09 mu M and was noncytotoxic to Vero cells. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ZEARALENONE PRODUCTION ; TOXIN EQUISETIN ; A-C ; METABOLITES ; ANTIBACTERIAL |
| 资助项目 | NSTDA Chair Professor grant of the Crown Property Bureau Foundation[00000000] ; National Science and Technology Development Agency[00000000] ; Thailand Research Fund[DBG5980001] ; NSFC-TRF[81561148011] ; Faculty of Science, Prince of Songkla University[00000000] ; Center of Excellence for Innovation in Chemistry (PERCH-CIC)[00000000] ; Graduate School, Prince of Songkla University[00000000] ; Department of Chemistry, Faculty of Science, Prince of Songkla University[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000384776300018 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275857]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Rukachaisirikul, Vatcharin |
| 作者单位 | 1.Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Songkhla, Thailand; 2.Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk, Klongluang 12120, Pathumthani, Thailand; 5.Prince Songkla Univ, Fac Sci, Nat Prod Res Ctr Excellence, Hat Yai 90112, Songkhla, Thailand; 6.Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90112, Songkhla, Thailand; |
| 推荐引用方式 GB/T 7714 | Saetang, Praphatsorn,Rukachaisirikul, Vatcharin,Phongpaichit, Souwalak,et al. beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123[J]. TETRAHEDRON,2016,72(41):6421-6427. |
| APA | Saetang, Praphatsorn.,Rukachaisirikul, Vatcharin.,Phongpaichit, Souwalak.,Sakayaroj, Jariya.,Shi, Xiaofan.,...&Shen, Xu.(2016).beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123.TETRAHEDRON,72(41),6421-6427. |
| MLA | Saetang, Praphatsorn,et al."beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123".TETRAHEDRON 72.41(2016):6421-6427. |
入库方式： OAI收割
来源：上海药物研究所
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