中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 国家新药筛选中心
miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle

文献类型：期刊论文

作者Zhang, Duo15; Li, Yan15; Yao, Xuan15; Wang, Hui3,15,15; Zhao, Lei14; Jiang, Haowen13; Yao, Xiaohan15; Zhang, Shengjie15; Ye, Cheng15; Liu, Wei15
刊名CELL REPORTS
出版日期2016-07-19
卷号16期号:3页码:757-768
ISSN号2211-1247
DOI10.1016/j.celrep.2016.06.040
文献子类Article
英文摘要Understanding the fiber-type specification and metabolic switch in skeletal muscle provides insights into energy metabolism in physiology and diseases. Here, we show that miR-182 is highly expressed in fast-twitch muscle and negatively correlates with blood glucose level. miR-182 knockout mice display muscle loss, fast-to-slow fiber-type switching, and impaired glucose metabolism. Mechanistic studies reveal that miR-182 modulates glucose utilization in muscle by targeting FoxO1 and PDK4, which control fuel selection via the pyruvate dehydrogenase complex (PDHC). Short-term high-fat diet (HFD) feeding reduces muscle miR-182 levels by tumor necrosis factor alpha (TNF alpha), which contributes to the upregulation of FoxO1/PDK4. Restoration of miR-182 expression in HFD-fed mice induces a faster muscle phenotype, decreases muscle FoxO1/PDK4 levels, and improves glucose metabolism. Together, our work establishes miR-182 as a critical regulator that confers robust and precise controls on fuel usage and glucose homeostasis. Our study suggests that a metabolic shift toward a faster and more glycolytic phenotype is beneficial for glucose control.
WOS关键词HIGH-FAT DIET ; SKELETAL-MUSCLE ; INSULIN-RESISTANCE ; GENE-EXPRESSION ; MICRORNAS ; FOXO3 ; FLEXIBILITY ; DYSFUNCTION ; CONVERSION ; PATHWAYS
资助项目National Key Basic Research Program[2013CB967502] ; National Natural Science Foundation of China[31525012] ; National Natural Science Foundation of China[31371189] ; National Natural Science Foundation of China[31500959] ; National Natural Science Foundation of China[81570768] ; National Natural Science Foundation of China[31070679] ; National Natural Science Foundation of China[31100550] ; National Natural Science Foundation of China[81201476] ; National Natural Science Foundation of China[81172009] ; National Natural Science Foundation of China[81372168] ; National Natural Science Foundation of China[81302820] ; National Natural Science Foundation of China[81522014] ; National Natural Science Foundation of China[81371059] ; National Natural Science Foundation of China[81402209] ; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences[SIBS2012004] ; CAS/SAFEA International Partnership Program for Creative Research Teams[00000000] ; Shanghai Charity Foundation (The Special Fund for DMD)[00000000] ; Xuhui Central Hospital (Shanghai, China)[00000000] ; Zhejiang Provincial Natural Science Foundation of China[LR13H120001] ; NHFPC[201472911] ; Wenzhou Science and Technology Innovation Team Project[C20150004]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000380264200015
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/275952]  
专题国家新药筛选中心
药物安全性评价中心
通讯作者Jin, Zi-Bing; Ying, Hao
作者单位1.Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Minist Educ,Key Lab Metab & Mol Med, Shanghai 200032, Peoples R China;
2.Natl Cardiovasc Ctr, Dept Epidemiol, Suita, Osaka 5658565, Japan;
3.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China;
4.Wenzhou Med Univ, State Key Lab Cultivat Base, Lab Stem Cell & Retinal Regenerat, Div Ophthalm Genet,Eye Hosp, Wenzhou 325027, Peoples R China;
5.Minist Hlth, Key Lab Vis Sci, Wenzhou 325027, Peoples R China;
6.Wenzhou Med Univ, Inst Stem Cell Res, Wenzhou 325027, Peoples R China
7.Fudan Univ, Ctr Canc, Dept Head & Neck Surg, Shanghai 200032, Peoples R China;
8.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China;
9.Fudan Univ, Huandong Hosp, Dept Orthoped Surg, Shanghai 200040, Peoples R China;
10.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Duo,Li, Yan,Yao, Xuan,et al. miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle[J]. CELL REPORTS,2016,16(3):757-768.
APA Zhang, Duo.,Li, Yan.,Yao, Xuan.,Wang, Hui.,Zhao, Lei.,...&Ying, Hao.(2016).miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle.CELL REPORTS,16(3),757-768.
MLA Zhang, Duo,et al."miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle".CELL REPORTS 16.3(2016):757-768.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。