Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
文献类型：期刊论文
| 作者 | Du, Changsheng2; Duan, Yanhui2; Wei, Wei2; Cai, Yingying2; Chai, Hui1; Lv, Jie2; Du, Xiling2; Zhu, Jian2; Xie, Xin1,2
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2016-04 |
| 卷号 | 7 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms11120 |
| 文献子类 | Article |
| 英文摘要 | Multiple sclerosis (MS) is characterized by autoimmune damage to the central nervous system. All the current drugs for MS target the immune system. Although effective in reducing new lesions, they have limited effects in preventing the progression of disability. Promoting oligodendrocyte-mediated remyelination and recovery of neurons are the new directions of MS therapy. The endogenous opioid system, consisting of MOR, DOR, KOR and their ligands, has been suggested to participate in the pathogenesis of MS. However, the exact receptor and mechanism remain elusive. Here we show that genetic deletion of KOR exacerbates experimental autoimmune encephalomyelitis, whereas activating KOR with agonists alleviates the symptoms. KOR does not affect immune cell differentiation and function. Instead, it promotes oligodendrocyte differentiation and myelination both in vitro and in vivo. Our study suggests that targeting KOR might be an intriguing way to develop new MS therapies that may complement the existing immunosuppressive approaches. |
| WOS关键词 | LOW-DOSE NALTREXONE ; QUALITY-OF-LIFE ; MULTIPLE-SCLEROSIS ; ENDOGENOUS OPIOIDS ; ENDOTHELIAL-CELLS ; AGONIST U50,488H ; PILOT TRIAL ; SPINAL-CORD ; CNS ; PATHOGENESIS |
| 资助项目 | Chinese Academy of Sciences[XDA01040301] ; Ministry of Science and Technology of China[2015CB964503] ; Ministry of Science and Technology of China[2014CB541903] ; Ministry of Science and Technology of China[2014CB541906] ; Ministry of Science and Technology of China[2012CB910404] ; National Natural Science Foundation of China[81425024] ; National Natural Science Foundation of China[31171348] ; National Natural Science Foundation of China[31371414] ; Innovation Program of Shanghai Municipal Education Commission[14zz042] ; State Key Laboratory of Drug Research[SIMM1302KF-09] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000373530300001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276093]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Xie, Xin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Lab Receptor Based Bio Med, Shanghai 200092, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Du, Changsheng,Duan, Yanhui,Wei, Wei,et al. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination[J]. NATURE COMMUNICATIONS,2016,7. |
| APA | Du, Changsheng.,Duan, Yanhui.,Wei, Wei.,Cai, Yingying.,Chai, Hui.,...&Xie, Xin.(2016).Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.NATURE COMMUNICATIONS,7. |
| MLA | Du, Changsheng,et al."Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination".NATURE COMMUNICATIONS 7(2016). |
入库方式： OAI收割
来源：上海药物研究所
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