Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity
文献类型：期刊论文
| 作者 | Zhu, Yan2,4; Xu, Junjiu3; Li, Zhao2,4; Xie, Shuwu2,4; Thou, Jieyun2,4; Guo, Xiangjie2,4; Zhou, Xianying2,4; Li, Guoting2; Zhong, Ruihua2; Ma, Aying1,2 |
| 刊名 | JOURNAL OF FUNCTIONAL FOODS
 |
| 出版日期 | 2015-10 |
| 卷号 | 18页码:73-82 |
| 关键词 | Ginsenoside Rh2 ER alpha c-Src p38 MAPK Uterine leiomyoma |
| ISSN号 | 1756-4646 |
| DOI | 10.1016/j.jff.2015.06.057 |
| 文献子类 | Article |
| 英文摘要 | Panax ginseng is widely used as a functional food in Asia because of its bioactivities. Here, we report that ginsenoside Rh2, an extract of red Panax ginseng, suppressed growth of uterine leiomyomas (ULs) in a rat model and decreased serum hormone levels in a dose-dependent manner. Rh2 also inhibited the growth of cultured human UL cells in vitro. After Rh2 treatment, cells showed morphological changes that were consistent with apoptosis. Using ELISA, real-time RT-PCR, and Western blot methods, we found that Rh2 significantly reduced the activity of oestrogen receptor alpha (ER alpha) and c-Src, increased p38 MAPK activity, and reversed ER alpha activity mediated by PP2 and SB203580, specific inhibitors of c-Src and p38 MAPK, respectively, in UL cells. These findings provide a novel mechanism for the anti-proliferative efficacy of Rh2 that likely involves regulating ER alpha/Src/p38 MAPK activity. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ESTROGEN-RECEPTOR-ALPHA ; BREAST-CANCER ; ER-ALPHA ; C-SRC ; MODEL ; PHOSPHORYLATION ; EXPRESSION ; CELLS ; GESTRINONE ; ACTIVATION |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000367757400008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276375]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Zhu, Yan |
| 作者单位 | 1.Fudan Univ, Shanghai 200032, Peoples R China 2.Shanghai Inst Planned Parenthood Res, Dept Reprod Pharmacol, Shanghai 200032, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, Shanghai 201203, Peoples R China; 4.Shanghai ETR Ctr Reprod Hlth Drug & Devices, NPFPC Key Lab Contracept & Devices, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Yan,Xu, Junjiu,Li, Zhao,et al. Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity[J]. JOURNAL OF FUNCTIONAL FOODS,2015,18:73-82. |
| APA | Zhu, Yan.,Xu, Junjiu.,Li, Zhao.,Xie, Shuwu.,Thou, Jieyun.,...&Ma, Aying.(2015).Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity.JOURNAL OF FUNCTIONAL FOODS,18,73-82. |
| MLA | Zhu, Yan,et al."Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity".JOURNAL OF FUNCTIONAL FOODS 18(2015):73-82. |
入库方式： OAI收割
来源：上海药物研究所
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