Application of chemical biology in target identification and drug discovery
文献类型：期刊论文
| 作者 | Zhu, Yue1,2; Xiao, Ting1,2; Lei, Saifei1,2; Zhou, Fulai1,2; Wang, Ming-Wei1,2,3
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2015-09 |
| 卷号 | 38期号:9页码:1642-1650 |
| 关键词 | Chemical biology Genomics Proteomics Drug discovery Target validation High-throughput screening (HTS) |
| ISSN号 | 0253-6269 |
| DOI | 10.1007/s12272-015-0643-2 |
| 文献子类 | Review |
| 英文摘要 | Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological problems through searching previously unknown targets for pharmacologically active small molecules or finding ligands for well-defined drug targets. It is a powerful tool to study how these small molecules interact with their respective targets, as well as their roles in signal transduction, molecular recognition and cell functions. There have been an increasing number of new therapeutic targets being identified and subsequently validated as a result of advances in functional genomics, which in turn led to the discovery of numerous active small molecules via a variety of high-throughput screening initiatives. In this review, we highlight some applications of chemical biology in the context of drug discovery. |
| WOS关键词 | SCINTILLATION PROXIMITY ASSAY ; FLUORESCENCE POLARIZATION ASSAY ; PROTEIN-COUPLED RECEPTORS ; CDNA MICROARRAY ; CANDIDA-ALBICANS ; JAK INHIBITOR ; BINDING ASSAY ; KINASE ; TECHNOLOGY ; EXPRESSION |
| 资助项目 | National Health and Family Planning Commission[2012ZX09304-011] ; National Health and Family Planning Commission[2013ZX09401003-005] ; National Health and Family Planning Commission[2013ZX09507001] ; National Health and Family Planning Commission[2013ZX09507-002] ; Shanghai Science and Technology Development Fund[13DZ2290300] ; Shanghai Science and Technology Development Fund[15DZ2291600] ; CAS-Novo Nordisk Research Fund[00000000] ; Thousand Talents Program in China[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000361445000009 |
| 出版者 | PHARMACEUTICAL SOC KOREA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276410]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Wang, Ming-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Yue,Xiao, Ting,Lei, Saifei,et al. Application of chemical biology in target identification and drug discovery[J]. ARCHIVES OF PHARMACAL RESEARCH,2015,38(9):1642-1650. |
| APA | Zhu, Yue,Xiao, Ting,Lei, Saifei,Zhou, Fulai,&Wang, Ming-Wei.(2015).Application of chemical biology in target identification and drug discovery.ARCHIVES OF PHARMACAL RESEARCH,38(9),1642-1650. |
| MLA | Zhu, Yue,et al."Application of chemical biology in target identification and drug discovery".ARCHIVES OF PHARMACAL RESEARCH 38.9(2015):1642-1650. |
入库方式： OAI收割
来源：上海药物研究所
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