The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo
文献类型：期刊论文
| 作者 | Luo, Xiao1,2; Li, Ting1,2; Zhu, Yue1,2; Dai, Yunbin1,2; Zhao, Jianwei1,2; Guo, Zhan-Yun3; Wang, Ming-Wei1,2
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| 刊名 | BIOCHEMICAL JOURNAL
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| 出版日期 | 2015-03-15 |
| 卷号 | 466页码:467-473 |
| 关键词 | Type 2 diabetes mellitus GLP-1 hypoglycaemic effect INSL5 insulin RXFP4 |
| ISSN号 | 0264-6021 |
| DOI | 10.1042/BJ20141113 |
| 文献子类 | Article |
| 英文摘要 | Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein-coupled receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), but its precise biological functions are largely unknown. Recent studies suggest that INSL5/RXFP4 is involved in the control of food intake and glucose homoeostasis. We report in the present study that RXFP4 is present in the mouse insulinoma cell line MIN6 and INSL5 augments glucose-stimulated insulin secretion (GSIS) both in vitro and in vivo. RXFP4 is also expressed in the mouse intestinal L-cell line GLUTag and INSL5 is capable of potentiating glucose-dependent glucagon-like peptide-1 (GLP-1) secretion in GLUTag cells. We propose that the insulinotrophic effect of INSL5 is probably mediated through stimulation of insulin/GLP-1 secretion and the INSL5/RXFP4 system may be a potential therapeutic target for Type 2 diabetes. |
| WOS关键词 | GLUCOSE-HOMEOSTASIS ; BETA-CELLS ; SECRETION ; RECEPTORS ; INSL5 ; G-PROTEIN-COUPLED-RECEPTOR-119 ; IDENTIFICATION ; DISCOVERY ; AGONIST ; RXFP4 |
| 资助项目 | National Health and Family Planning Commission of China[2012ZX09304-011] ; National Health and Family Planning Commission of China[2013ZX09401003-005] ; National Health and Family Planning Commission of China[2013ZX09507-001] ; National Health and Family Planning Commission of China[2013ZX09507-002] ; Shanghai Science and Technology Development Fund[13DZ2290300] ; Thousand Talents Program in China[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000351687000004 |
| 出版者 | PORTLAND PRESS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276603]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Wang, Ming-Wei |
| 作者单位 | 1.Natl Ctr Drug Screening, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 200031, Peoples R China; 3.Tongji Univ, Coll Life Sci & Technol, Inst Prot Res, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Xiao,Li, Ting,Zhu, Yue,et al. The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo[J]. BIOCHEMICAL JOURNAL,2015,466:467-473. |
| APA | Luo, Xiao.,Li, Ting.,Zhu, Yue.,Dai, Yunbin.,Zhao, Jianwei.,...&Wang, Ming-Wei.(2015).The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo.BIOCHEMICAL JOURNAL,466,467-473. |
| MLA | Luo, Xiao,et al."The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo".BIOCHEMICAL JOURNAL 466(2015):467-473. |
入库方式： OAI收割
来源：上海药物研究所
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