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miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor

文献类型：期刊论文

作者Chu, Bo3,4; Zhong, Liangwen3,4; Dou, Shuang3,4; Wang, Jun3,4; Li, Jianmin2; Wang, Mingwei1; Shi, Qinghua3,4; Mei, Yide3,4; Wu, Mian3,4
刊名JOURNAL OF MOLECULAR CELL BIOLOGY
出版日期2015-02
卷号7期号:1页码:12-22
关键词miR-181 LIF Emx2 embryo implantation
ISSN号1674-2788
DOI10.1093/jmcb/mjv006
文献子类Article
英文摘要Embryo implantation is a crucial step in mammalian reproduction. However, little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation. Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation. Both transient and prolonged transgenic expression of miR-181 led to impaired implantation, which can be rescued by exogenous administration of leukemia inhibitory factor (LIF). Mechanistically, miR-181 is able to directly target LIF and downregulate LIF expression, thereby inhibiting embryo implantation. We also show that miR-181 expression is regulated by the transcriptional factor Emx2, and the Emx2-miR-181 axis plays an important role in regulating embryo implantation. Taken together, these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF, and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects.
WOS关键词EPIDERMAL-GROWTH-FACTOR ; MOUSE UTERUS ; FACTOR LIF ; BLASTOCYST IMPLANTATION ; MAMMALIAN REPRODUCTION ; SIGNALING PATHWAYS ; SPATIAL REGULATION ; ESTROGEN-RECEPTOR ; EARLY-PREGNANCY ; EXPRESSION
资助项目Ministry of Science and Technology of China[2011CB966302] ; Ministry of Science and Technology of China[2013CB947900] ; Ministry of Science and Technology of China[2014CB910601] ; Ministry of Science and Technology of China[2013CB945502] ; National Natural Science Foundation of China[81430065] ; National Natural Science Foundation of China[31371388] ; Fundamental Research Funds For Central Universities[WK2070000034] ; Ministry of Education of China[20123402130006]
WOS研究方向Cell Biology
语种英语
CSCD记录号CSCD:5380324
WOS记录号WOS:000350228600003
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/276648]  
专题国家新药筛选中心
通讯作者Shi, Qinghua
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Nanjing Med Univ, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China;
3.Univ Sci & Technol China, Med Ctr, Hefei 230027, Peoples R China;
4.Univ Sci & Technol China, Sch Life Sci, Innovat Ctr Cell Biol, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Peoples R China;
推荐引用方式
GB/T 7714		 Chu, Bo,Zhong, Liangwen,Dou, Shuang,et al. miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(1):12-22.
APA Chu, Bo.,Zhong, Liangwen.,Dou, Shuang.,Wang, Jun.,Li, Jianmin.,...&Wu, Mian.(2015).miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor.JOURNAL OF MOLECULAR CELL BIOLOGY,7(1),12-22.
MLA Chu, Bo,et al."miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor".JOURNAL OF MOLECULAR CELL BIOLOGY 7.1(2015):12-22.

入库方式： OAI收割

来源：上海药物研究所

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